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Biochemical and biophysical characterization of the OXA-48-like carbapenemase OXA-436
The crystal structure of the class D β-lactamase OXA-436 was solved to a resolution of 1.80 Å. Higher catalytic rates were found at higher temperatures for the clinically important antibiotic imipenem, indicating better adaptation of OXA-436 to its mesophilic host than OXA-48, which is believed to o...
Autores principales: | Lund, Bjarte Aarmo, Thomassen, Ane Molden, Carlsen, Trine Josefine Warg, Leiros, Hanna-Kirsti Schrøder |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8411929/ https://www.ncbi.nlm.nih.gov/pubmed/34473108 http://dx.doi.org/10.1107/S2053230X21008645 |
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