IDH‐mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature

Isocitrate dehydrogenase (IDH) mutations are rare in pediatric and adolescent gliomas. We recently identified three adolescent/young adult (AYA) patients with IDH‐mutant low grade gliomas of the brainstem with several key clinicopathologic and molecular features in common. We discuss these three cas...

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Autores principales: Chang, Ellen K., Smith‐Cohn, Matthew A., Tamrazi, Benita, Ji, Jianling, Krieger, Mark, Holdhoff, Matthias, Eberhart, Charles G., Margol, Ashley S., Cotter, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412065/
https://www.ncbi.nlm.nih.gov/pubmed/33960568
http://dx.doi.org/10.1111/bpa.12959
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author Chang, Ellen K.
Smith‐Cohn, Matthew A.
Tamrazi, Benita
Ji, Jianling
Krieger, Mark
Holdhoff, Matthias
Eberhart, Charles G.
Margol, Ashley S.
Cotter, Jennifer A.
author_facet Chang, Ellen K.
Smith‐Cohn, Matthew A.
Tamrazi, Benita
Ji, Jianling
Krieger, Mark
Holdhoff, Matthias
Eberhart, Charles G.
Margol, Ashley S.
Cotter, Jennifer A.
author_sort Chang, Ellen K.
collection PubMed
description Isocitrate dehydrogenase (IDH) mutations are rare in pediatric and adolescent gliomas. We recently identified three adolescent/young adult (AYA) patients with IDH‐mutant low grade gliomas of the brainstem with several key clinicopathologic and molecular features in common. We discuss these three cases and review the current literature.[Image: see text]
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spelling pubmed-84120652021-09-03 IDH‐mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature Chang, Ellen K. Smith‐Cohn, Matthew A. Tamrazi, Benita Ji, Jianling Krieger, Mark Holdhoff, Matthias Eberhart, Charles G. Margol, Ashley S. Cotter, Jennifer A. Brain Pathol Letters to the Editor Isocitrate dehydrogenase (IDH) mutations are rare in pediatric and adolescent gliomas. We recently identified three adolescent/young adult (AYA) patients with IDH‐mutant low grade gliomas of the brainstem with several key clinicopathologic and molecular features in common. We discuss these three cases and review the current literature.[Image: see text] John Wiley and Sons Inc. 2021-05-07 /pmc/articles/PMC8412065/ /pubmed/33960568 http://dx.doi.org/10.1111/bpa.12959 Text en © 2021 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Letters to the Editor
Chang, Ellen K.
Smith‐Cohn, Matthew A.
Tamrazi, Benita
Ji, Jianling
Krieger, Mark
Holdhoff, Matthias
Eberhart, Charles G.
Margol, Ashley S.
Cotter, Jennifer A.
IDH‐mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature
title IDH‐mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature
title_full IDH‐mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature
title_fullStr IDH‐mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature
title_full_unstemmed IDH‐mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature
title_short IDH‐mutant brainstem gliomas in adolescent and young adult patients: Report of three cases and review of the literature
title_sort idh‐mutant brainstem gliomas in adolescent and young adult patients: report of three cases and review of the literature
topic Letters to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412065/
https://www.ncbi.nlm.nih.gov/pubmed/33960568
http://dx.doi.org/10.1111/bpa.12959
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