Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits

TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late‐onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b−/− mouse model. By using high‐power microscopy and bulk RNA s...

Descripción completa

Detalles Bibliográficos
Autores principales: Rademakers, Rosa, Nicholson, Alexandra M., Ren, Yingxue, Koga, Shunsuke, Nguyen, Hung Phuoc, Brooks, Mieu, Qiao, Wenhui, Quicksall, Zachary S., Matchett, Billie, Perkerson, Ralph B., Kurti, Aishe, Castanedes‐Casey, Monica, Phillips, Virginia, Librero, Ariston L, Fernandez De Castro, Cristhoper H., Baker, Matthew C., Roemer, Shanu F., Murray, Melissa E., Asmann, Yan, Fryer, John D., Bu, Guojun, Dickson, Dennis W., Zhou, Xiaolai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Letter to the Editors
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412084/
https://www.ncbi.nlm.nih.gov/pubmed/33709463
http://dx.doi.org/10.1111/bpa.12945
Descripción
Sumario:TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late‐onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b−/− mouse model. By using high‐power microscopy and bulk RNA sequencing, the authors further identify lysosomal and immune dysfunction as potential underlying mechanisms of the Purkinje cell loss. [Image: see text]

Ejemplares similares