Cargando…
Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits
TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late‐onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b−/− mouse model. By using high‐power microscopy and bulk RNA s...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412084/ https://www.ncbi.nlm.nih.gov/pubmed/33709463 http://dx.doi.org/10.1111/bpa.12945 |
| _version_ | 1783747387984969728 |
|---|---|
| author | Rademakers, Rosa Nicholson, Alexandra M. Ren, Yingxue Koga, Shunsuke Nguyen, Hung Phuoc Brooks, Mieu Qiao, Wenhui Quicksall, Zachary S. Matchett, Billie Perkerson, Ralph B. Kurti, Aishe Castanedes‐Casey, Monica Phillips, Virginia Librero, Ariston L Fernandez De Castro, Cristhoper H. Baker, Matthew C. Roemer, Shanu F. Murray, Melissa E. Asmann, Yan Fryer, John D. Bu, Guojun Dickson, Dennis W. Zhou, Xiaolai |
| author_facet | Rademakers, Rosa Nicholson, Alexandra M. Ren, Yingxue Koga, Shunsuke Nguyen, Hung Phuoc Brooks, Mieu Qiao, Wenhui Quicksall, Zachary S. Matchett, Billie Perkerson, Ralph B. Kurti, Aishe Castanedes‐Casey, Monica Phillips, Virginia Librero, Ariston L Fernandez De Castro, Cristhoper H. Baker, Matthew C. Roemer, Shanu F. Murray, Melissa E. Asmann, Yan Fryer, John D. Bu, Guojun Dickson, Dennis W. Zhou, Xiaolai |
| author_sort | Rademakers, Rosa |
| collection | PubMed |
| description | TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late‐onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b−/− mouse model. By using high‐power microscopy and bulk RNA sequencing, the authors further identify lysosomal and immune dysfunction as potential underlying mechanisms of the Purkinje cell loss. [Image: see text] |
| format | Online Article Text |
| id | pubmed-8412084 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-84120842021-09-03 Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits Rademakers, Rosa Nicholson, Alexandra M. Ren, Yingxue Koga, Shunsuke Nguyen, Hung Phuoc Brooks, Mieu Qiao, Wenhui Quicksall, Zachary S. Matchett, Billie Perkerson, Ralph B. Kurti, Aishe Castanedes‐Casey, Monica Phillips, Virginia Librero, Ariston L Fernandez De Castro, Cristhoper H. Baker, Matthew C. Roemer, Shanu F. Murray, Melissa E. Asmann, Yan Fryer, John D. Bu, Guojun Dickson, Dennis W. Zhou, Xiaolai Brain Pathol Letter to the Editors TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late‐onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b−/− mouse model. By using high‐power microscopy and bulk RNA sequencing, the authors further identify lysosomal and immune dysfunction as potential underlying mechanisms of the Purkinje cell loss. [Image: see text] John Wiley and Sons Inc. 2021-03-11 /pmc/articles/PMC8412084/ /pubmed/33709463 http://dx.doi.org/10.1111/bpa.12945 Text en © 2021 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| spellingShingle | Letter to the Editors Rademakers, Rosa Nicholson, Alexandra M. Ren, Yingxue Koga, Shunsuke Nguyen, Hung Phuoc Brooks, Mieu Qiao, Wenhui Quicksall, Zachary S. Matchett, Billie Perkerson, Ralph B. Kurti, Aishe Castanedes‐Casey, Monica Phillips, Virginia Librero, Ariston L Fernandez De Castro, Cristhoper H. Baker, Matthew C. Roemer, Shanu F. Murray, Melissa E. Asmann, Yan Fryer, John D. Bu, Guojun Dickson, Dennis W. Zhou, Xiaolai Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits |
| title | Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits |
| title_full | Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits |
| title_fullStr | Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits |
| title_full_unstemmed | Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits |
| title_short | Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits |
| title_sort | loss of tmem106b leads to cerebellum purkinje cell death and motor deficits |
| topic | Letter to the Editors |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412084/ https://www.ncbi.nlm.nih.gov/pubmed/33709463 http://dx.doi.org/10.1111/bpa.12945 |
| work_keys_str_mv | AT rademakersrosa lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT nicholsonalexandram lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT renyingxue lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT kogashunsuke lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT nguyenhungphuoc lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT brooksmieu lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT qiaowenhui lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT quicksallzacharys lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT matchettbillie lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT perkersonralphb lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT kurtiaishe lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT castanedescaseymonica lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT phillipsvirginia lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT libreroaristonl lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT fernandezdecastrocristhoperh lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT bakermatthewc lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT roemershanuf lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT murraymelissae lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT asmannyan lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT fryerjohnd lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT buguojun lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT dicksondennisw lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits AT zhouxiaolai lossoftmem106bleadstocerebellumpurkinjecelldeathandmotordeficits |