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Risk factors associated with the development of delirium in general ICU patients. A prospective observational study

OBJECTIVE: We aimed to analyze risk factors related to the development of delirium, aiming for early intervention in patients with greater risk. MATERIAL AND METHODS: Observational study, including prospectively collected patients treated in a single general ICU. These were classified into two group...

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Autores principales: Lobo-Valbuena, Beatriz, Gordo, Federico, Abella, Ana, Garcia-Manzanedo, Sofía, Garcia-Arias, Maria-Mercedes, Torrejón, Inés, Varillas-Delgado, David, Molina, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412262/
https://www.ncbi.nlm.nih.gov/pubmed/34473734
http://dx.doi.org/10.1371/journal.pone.0255522
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author Lobo-Valbuena, Beatriz
Gordo, Federico
Abella, Ana
Garcia-Manzanedo, Sofía
Garcia-Arias, Maria-Mercedes
Torrejón, Inés
Varillas-Delgado, David
Molina, Rosario
author_facet Lobo-Valbuena, Beatriz
Gordo, Federico
Abella, Ana
Garcia-Manzanedo, Sofía
Garcia-Arias, Maria-Mercedes
Torrejón, Inés
Varillas-Delgado, David
Molina, Rosario
author_sort Lobo-Valbuena, Beatriz
collection PubMed
description OBJECTIVE: We aimed to analyze risk factors related to the development of delirium, aiming for early intervention in patients with greater risk. MATERIAL AND METHODS: Observational study, including prospectively collected patients treated in a single general ICU. These were classified into two groups, according to whether they developed delirium or not (screening performed using CAM-ICU tool). Demographics and clinical data were analyzed. Multivariate logistic regression analyses were performed to quantify existing associations. RESULTS: 1462 patients were included. 93 developed delirium (incidence: 6.3%). These were older, scored higher on the Clinical Frailty Scale, on the risk scores on admission (SAPS-3 and SOFA), and had a greater number of organ failures (OF). We observed more incidence of delirium in patients who (a) presented more than two OF (20.4%; OR 4.9; CI95%: 2.9–8.2), and (b) were more than 74 years old albeit having <2 OF (8.6%; OR 2.1; CI95%: 1.3–3.5). Patients who developed delirium had longer ICU and hospital length-of-stays and a higher rate of readmission. CONCLUSIONS: The highest risk observed for developing delirium clustered in patients who presented more than 2 OF and patients over 74 years old. The detection of patients at high risk for developing delirium could imply a change in management and improved quality of care.
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spelling pubmed-84122622021-09-03 Risk factors associated with the development of delirium in general ICU patients. A prospective observational study Lobo-Valbuena, Beatriz Gordo, Federico Abella, Ana Garcia-Manzanedo, Sofía Garcia-Arias, Maria-Mercedes Torrejón, Inés Varillas-Delgado, David Molina, Rosario PLoS One Research Article OBJECTIVE: We aimed to analyze risk factors related to the development of delirium, aiming for early intervention in patients with greater risk. MATERIAL AND METHODS: Observational study, including prospectively collected patients treated in a single general ICU. These were classified into two groups, according to whether they developed delirium or not (screening performed using CAM-ICU tool). Demographics and clinical data were analyzed. Multivariate logistic regression analyses were performed to quantify existing associations. RESULTS: 1462 patients were included. 93 developed delirium (incidence: 6.3%). These were older, scored higher on the Clinical Frailty Scale, on the risk scores on admission (SAPS-3 and SOFA), and had a greater number of organ failures (OF). We observed more incidence of delirium in patients who (a) presented more than two OF (20.4%; OR 4.9; CI95%: 2.9–8.2), and (b) were more than 74 years old albeit having <2 OF (8.6%; OR 2.1; CI95%: 1.3–3.5). Patients who developed delirium had longer ICU and hospital length-of-stays and a higher rate of readmission. CONCLUSIONS: The highest risk observed for developing delirium clustered in patients who presented more than 2 OF and patients over 74 years old. The detection of patients at high risk for developing delirium could imply a change in management and improved quality of care. Public Library of Science 2021-09-02 /pmc/articles/PMC8412262/ /pubmed/34473734 http://dx.doi.org/10.1371/journal.pone.0255522 Text en © 2021 Lobo-Valbuena et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lobo-Valbuena, Beatriz
Gordo, Federico
Abella, Ana
Garcia-Manzanedo, Sofía
Garcia-Arias, Maria-Mercedes
Torrejón, Inés
Varillas-Delgado, David
Molina, Rosario
Risk factors associated with the development of delirium in general ICU patients. A prospective observational study
title Risk factors associated with the development of delirium in general ICU patients. A prospective observational study
title_full Risk factors associated with the development of delirium in general ICU patients. A prospective observational study
title_fullStr Risk factors associated with the development of delirium in general ICU patients. A prospective observational study
title_full_unstemmed Risk factors associated with the development of delirium in general ICU patients. A prospective observational study
title_short Risk factors associated with the development of delirium in general ICU patients. A prospective observational study
title_sort risk factors associated with the development of delirium in general icu patients. a prospective observational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412262/
https://www.ncbi.nlm.nih.gov/pubmed/34473734
http://dx.doi.org/10.1371/journal.pone.0255522
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