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Biomimetic Polydopamine-Modified Silk Fibroin/Curcumin Nanofibrous Scaffolds for Chemo-photothermal Therapy of Bone Tumor
[Image: see text] The simultaneous therapy of tumor recurrence and bone defects resulting from surgical resection of osteosarcoma is still a challenge in the clinic. Combination therapy based on a localized drug-delivery system shows great promise in the treatment of osteosarcoma. Herein, bifunction...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412900/ https://www.ncbi.nlm.nih.gov/pubmed/34497912 http://dx.doi.org/10.1021/acsomega.1c02903 |
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author | Meng, Zhiyuan Liu, Yichao Xu, Kexiang Sun, Xing Yu, Qingwen Wu, Zhongqing Zhao, Zheng |
author_facet | Meng, Zhiyuan Liu, Yichao Xu, Kexiang Sun, Xing Yu, Qingwen Wu, Zhongqing Zhao, Zheng |
author_sort | Meng, Zhiyuan |
collection | PubMed |
description | [Image: see text] The simultaneous therapy of tumor recurrence and bone defects resulting from surgical resection of osteosarcoma is still a challenge in the clinic. Combination therapy based on a localized drug-delivery system shows great promise in the treatment of osteosarcoma. Herein, bifunctional polydopamine (PDA)-modified curcumin (CM)-loaded silk fibroin (SF) composite (SF/CM-PDA) nanofibrous scaffolds, which combined photothermal therapy with chemotherapy to synergistically enhance osteosarcoma therapy, were prepared by PDA coating of the SF/CM nanofibrous scaffolds fabricated by supercritical carbon dioxide (SC-CO(2)) technology. The PDA coating improved hydrophilicity and mechanical strength of the SF/CM scaffolds. The SF/CM-PDA scaffolds present good photothermal conversion capacity and excellent photostability. The low pH and near-infrared (NIR) irradiation could effectively accelerate release of CM in the SF/CM-PDA scaffolds. The in vitro anticancer results indicated that the biocompatible SF/CM-PDA scaffolds had a long-term, stable, and superior anticancer effect compared to pure CM. Furthermore, the SF/CM-PDA scaffolds significantly increased the growth inhibition of osteosarcoma MG-63 cells under NIR irradiation (808 nm and 1.3 W/cm(2)). Besides, the SF/CM-PDA scaffolds could enhance osteoblast MC3T3-E1 cell proliferation in vitro when the mass ratio of CM was 0.05–0.5%. This work has therefore demonstrated that the bifunctional SF/CM-PDA scaffolds provide a competitive strategy for local osteosarcoma therapy and bone regeneration. |
format | Online Article Text |
id | pubmed-8412900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-84129002021-09-07 Biomimetic Polydopamine-Modified Silk Fibroin/Curcumin Nanofibrous Scaffolds for Chemo-photothermal Therapy of Bone Tumor Meng, Zhiyuan Liu, Yichao Xu, Kexiang Sun, Xing Yu, Qingwen Wu, Zhongqing Zhao, Zheng ACS Omega [Image: see text] The simultaneous therapy of tumor recurrence and bone defects resulting from surgical resection of osteosarcoma is still a challenge in the clinic. Combination therapy based on a localized drug-delivery system shows great promise in the treatment of osteosarcoma. Herein, bifunctional polydopamine (PDA)-modified curcumin (CM)-loaded silk fibroin (SF) composite (SF/CM-PDA) nanofibrous scaffolds, which combined photothermal therapy with chemotherapy to synergistically enhance osteosarcoma therapy, were prepared by PDA coating of the SF/CM nanofibrous scaffolds fabricated by supercritical carbon dioxide (SC-CO(2)) technology. The PDA coating improved hydrophilicity and mechanical strength of the SF/CM scaffolds. The SF/CM-PDA scaffolds present good photothermal conversion capacity and excellent photostability. The low pH and near-infrared (NIR) irradiation could effectively accelerate release of CM in the SF/CM-PDA scaffolds. The in vitro anticancer results indicated that the biocompatible SF/CM-PDA scaffolds had a long-term, stable, and superior anticancer effect compared to pure CM. Furthermore, the SF/CM-PDA scaffolds significantly increased the growth inhibition of osteosarcoma MG-63 cells under NIR irradiation (808 nm and 1.3 W/cm(2)). Besides, the SF/CM-PDA scaffolds could enhance osteoblast MC3T3-E1 cell proliferation in vitro when the mass ratio of CM was 0.05–0.5%. This work has therefore demonstrated that the bifunctional SF/CM-PDA scaffolds provide a competitive strategy for local osteosarcoma therapy and bone regeneration. American Chemical Society 2021-08-21 /pmc/articles/PMC8412900/ /pubmed/34497912 http://dx.doi.org/10.1021/acsomega.1c02903 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Meng, Zhiyuan Liu, Yichao Xu, Kexiang Sun, Xing Yu, Qingwen Wu, Zhongqing Zhao, Zheng Biomimetic Polydopamine-Modified Silk Fibroin/Curcumin Nanofibrous Scaffolds for Chemo-photothermal Therapy of Bone Tumor |
title | Biomimetic Polydopamine-Modified Silk Fibroin/Curcumin
Nanofibrous Scaffolds for Chemo-photothermal Therapy of Bone Tumor |
title_full | Biomimetic Polydopamine-Modified Silk Fibroin/Curcumin
Nanofibrous Scaffolds for Chemo-photothermal Therapy of Bone Tumor |
title_fullStr | Biomimetic Polydopamine-Modified Silk Fibroin/Curcumin
Nanofibrous Scaffolds for Chemo-photothermal Therapy of Bone Tumor |
title_full_unstemmed | Biomimetic Polydopamine-Modified Silk Fibroin/Curcumin
Nanofibrous Scaffolds for Chemo-photothermal Therapy of Bone Tumor |
title_short | Biomimetic Polydopamine-Modified Silk Fibroin/Curcumin
Nanofibrous Scaffolds for Chemo-photothermal Therapy of Bone Tumor |
title_sort | biomimetic polydopamine-modified silk fibroin/curcumin
nanofibrous scaffolds for chemo-photothermal therapy of bone tumor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412900/ https://www.ncbi.nlm.nih.gov/pubmed/34497912 http://dx.doi.org/10.1021/acsomega.1c02903 |
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