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A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease

Bone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with surrounding tissues. In this study, by analyzing bone a...

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Autores principales: Zhang, Xiao, Robles, Hero, Magee, Kristann L, Lorenz, Madelyn R, Wang, Zhaohua, Harris, Charles A, Craft, Clarissa S, Scheller, Erica L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412938/
https://www.ncbi.nlm.nih.gov/pubmed/34378533
http://dx.doi.org/10.7554/eLife.66275
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author Zhang, Xiao
Robles, Hero
Magee, Kristann L
Lorenz, Madelyn R
Wang, Zhaohua
Harris, Charles A
Craft, Clarissa S
Scheller, Erica L
author_facet Zhang, Xiao
Robles, Hero
Magee, Kristann L
Lorenz, Madelyn R
Wang, Zhaohua
Harris, Charles A
Craft, Clarissa S
Scheller, Erica L
author_sort Zhang, Xiao
collection PubMed
description Bone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with surrounding tissues. In this study, by analyzing bone and adipose tissues in the lipodystrophic ‘fat-free’ mouse, we define a novel, secondary adipogenesis pathway that relies on the recruitment of adiponectin-negative stromal progenitors. This pathway is unique to the bone marrow and is activated with age and in states of metabolic stress in the fat-free mouse model, resulting in the expansion of bone marrow adipocytes specialized for lipid storage with compromised lipid mobilization and cytokine expression within regions traditionally devoted to hematopoiesis. This finding further distinguishes bone marrow from peripheral adipocytes and contributes to our understanding of bone marrow adipocyte origins, adaptations, and relationships with surrounding tissues with age and disease.
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spelling pubmed-84129382021-09-03 A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease Zhang, Xiao Robles, Hero Magee, Kristann L Lorenz, Madelyn R Wang, Zhaohua Harris, Charles A Craft, Clarissa S Scheller, Erica L eLife Cell Biology Bone marrow adipocytes accumulate with age and in diverse disease states. However, their origins and adaptations in these conditions remain unclear, impairing our understanding of their context-specific endocrine functions and relationship with surrounding tissues. In this study, by analyzing bone and adipose tissues in the lipodystrophic ‘fat-free’ mouse, we define a novel, secondary adipogenesis pathway that relies on the recruitment of adiponectin-negative stromal progenitors. This pathway is unique to the bone marrow and is activated with age and in states of metabolic stress in the fat-free mouse model, resulting in the expansion of bone marrow adipocytes specialized for lipid storage with compromised lipid mobilization and cytokine expression within regions traditionally devoted to hematopoiesis. This finding further distinguishes bone marrow from peripheral adipocytes and contributes to our understanding of bone marrow adipocyte origins, adaptations, and relationships with surrounding tissues with age and disease. eLife Sciences Publications, Ltd 2021-08-11 /pmc/articles/PMC8412938/ /pubmed/34378533 http://dx.doi.org/10.7554/eLife.66275 Text en © 2021, Zhang et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Cell Biology
Zhang, Xiao
Robles, Hero
Magee, Kristann L
Lorenz, Madelyn R
Wang, Zhaohua
Harris, Charles A
Craft, Clarissa S
Scheller, Erica L
A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
title A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
title_full A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
title_fullStr A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
title_full_unstemmed A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
title_short A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
title_sort bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
topic Cell Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412938/
https://www.ncbi.nlm.nih.gov/pubmed/34378533
http://dx.doi.org/10.7554/eLife.66275
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