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Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory

The histone modification H3K27me3 plays a central role in Polycomb-mediated epigenetic silencing. H3K27me3 recruits and allosterically activates Polycomb Repressive Complex 2 (PRC2), which adds this modification to nearby histones, providing a read/write mechanism for inheritance through DNA replica...

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Detalles Bibliográficos
Autores principales:	Lövkvist, Cecilia, Mikulski, Pawel, Reeck, Svenja, Hartley, Matthew, Dean, Caroline, Howard, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Physics of Living Systems
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412945/ https://www.ncbi.nlm.nih.gov/pubmed/34473050 http://dx.doi.org/10.7554/eLife.66454

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