The Design and Optimization of Extractive Distillation for Separating the Acetone/n-Heptane Binary Azeotrope Mixture

[Image: see text] Acetone and n-heptane are common solvents in the pharmaceutical industry and they have been found in wastewater. Under atmospheric conditions, the mixture of these compounds creates a minimum-boiling azeotrope. The extractive distillation process with a high boiling solvent is commonly utilized to separate the azeotropes in the industry to minimize waste, reuse resources, achieve clean production, and preserve the environment. In this work, extractive distillation was applied to separate the binary azeotropic system of acetone and n-heptane in wastewater using butyl propionate as a solvent. The characteristics of the process are designed and simulated via Aspen Plus. The simulation results showed that to get a distillate containing at least 99.5 mass% acetone, a solvent-to-feed ratio of 1.4, a reflux ratio of 1.5, a number of stages of 30, a feed stage of 26, a solvent stage of 10, and a solvent temperature of 298.15 K were required. The optimum operating parameters of the process were also obtained using the NLP optimization method, with the minimum total annual cost as the objective function. While the process was operating in optimal mode, CO(2) emissions were calculated to be 0.0780 kg CO(2)/kg feed.