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A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer
Medicinal plants serve as a lead source of bioactive compounds and have been an integral part of day-to-day life in treating various disease conditions since ancient times. Withaferin A (WFA), a bioactive ingredient of Withania somnifera, has been used for health and medicinal purposes for its adapt...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413038/ https://www.ncbi.nlm.nih.gov/pubmed/34485538 http://dx.doi.org/10.1155/2021/9483433 |
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author | Dubey, Seema Singh, Manohar Nelson, Ariel Karan, Dev |
author_facet | Dubey, Seema Singh, Manohar Nelson, Ariel Karan, Dev |
author_sort | Dubey, Seema |
collection | PubMed |
description | Medicinal plants serve as a lead source of bioactive compounds and have been an integral part of day-to-day life in treating various disease conditions since ancient times. Withaferin A (WFA), a bioactive ingredient of Withania somnifera, has been used for health and medicinal purposes for its adaptogenic, anti-inflammatory, and anticancer properties long before the published literature came into existence. Nearly 25% of pharmaceutical drugs are derived from medicinal plants, classified as dietary supplements. The bioactive compounds in these supplements may serve as chemotherapeutic substances competent to inhibit or reverse the process of carcinogenesis. The role of WFA is appreciated to polarize tumor-suppressive Th1-type immune response inducing natural killer cell activity and may provide an opportunity to manipulate the tumor microenvironment at an early stage to inhibit tumor progression. This article signifies the cumulative information about the role of WFA in modulating antitumor immunity and its potential in targeting prostate cancer. |
format | Online Article Text |
id | pubmed-8413038 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-84130382021-09-03 A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer Dubey, Seema Singh, Manohar Nelson, Ariel Karan, Dev J Immunol Res Review Article Medicinal plants serve as a lead source of bioactive compounds and have been an integral part of day-to-day life in treating various disease conditions since ancient times. Withaferin A (WFA), a bioactive ingredient of Withania somnifera, has been used for health and medicinal purposes for its adaptogenic, anti-inflammatory, and anticancer properties long before the published literature came into existence. Nearly 25% of pharmaceutical drugs are derived from medicinal plants, classified as dietary supplements. The bioactive compounds in these supplements may serve as chemotherapeutic substances competent to inhibit or reverse the process of carcinogenesis. The role of WFA is appreciated to polarize tumor-suppressive Th1-type immune response inducing natural killer cell activity and may provide an opportunity to manipulate the tumor microenvironment at an early stage to inhibit tumor progression. This article signifies the cumulative information about the role of WFA in modulating antitumor immunity and its potential in targeting prostate cancer. Hindawi 2021-08-25 /pmc/articles/PMC8413038/ /pubmed/34485538 http://dx.doi.org/10.1155/2021/9483433 Text en Copyright © 2021 Seema Dubey et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Dubey, Seema Singh, Manohar Nelson, Ariel Karan, Dev A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer |
title | A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer |
title_full | A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer |
title_fullStr | A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer |
title_full_unstemmed | A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer |
title_short | A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer |
title_sort | perspective on withania somnifera modulating antitumor immunity in targeting prostate cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413038/ https://www.ncbi.nlm.nih.gov/pubmed/34485538 http://dx.doi.org/10.1155/2021/9483433 |
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