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A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer

Medicinal plants serve as a lead source of bioactive compounds and have been an integral part of day-to-day life in treating various disease conditions since ancient times. Withaferin A (WFA), a bioactive ingredient of Withania somnifera, has been used for health and medicinal purposes for its adapt...

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Autores principales: Dubey, Seema, Singh, Manohar, Nelson, Ariel, Karan, Dev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413038/
https://www.ncbi.nlm.nih.gov/pubmed/34485538
http://dx.doi.org/10.1155/2021/9483433
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author Dubey, Seema
Singh, Manohar
Nelson, Ariel
Karan, Dev
author_facet Dubey, Seema
Singh, Manohar
Nelson, Ariel
Karan, Dev
author_sort Dubey, Seema
collection PubMed
description Medicinal plants serve as a lead source of bioactive compounds and have been an integral part of day-to-day life in treating various disease conditions since ancient times. Withaferin A (WFA), a bioactive ingredient of Withania somnifera, has been used for health and medicinal purposes for its adaptogenic, anti-inflammatory, and anticancer properties long before the published literature came into existence. Nearly 25% of pharmaceutical drugs are derived from medicinal plants, classified as dietary supplements. The bioactive compounds in these supplements may serve as chemotherapeutic substances competent to inhibit or reverse the process of carcinogenesis. The role of WFA is appreciated to polarize tumor-suppressive Th1-type immune response inducing natural killer cell activity and may provide an opportunity to manipulate the tumor microenvironment at an early stage to inhibit tumor progression. This article signifies the cumulative information about the role of WFA in modulating antitumor immunity and its potential in targeting prostate cancer.
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spelling pubmed-84130382021-09-03 A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer Dubey, Seema Singh, Manohar Nelson, Ariel Karan, Dev J Immunol Res Review Article Medicinal plants serve as a lead source of bioactive compounds and have been an integral part of day-to-day life in treating various disease conditions since ancient times. Withaferin A (WFA), a bioactive ingredient of Withania somnifera, has been used for health and medicinal purposes for its adaptogenic, anti-inflammatory, and anticancer properties long before the published literature came into existence. Nearly 25% of pharmaceutical drugs are derived from medicinal plants, classified as dietary supplements. The bioactive compounds in these supplements may serve as chemotherapeutic substances competent to inhibit or reverse the process of carcinogenesis. The role of WFA is appreciated to polarize tumor-suppressive Th1-type immune response inducing natural killer cell activity and may provide an opportunity to manipulate the tumor microenvironment at an early stage to inhibit tumor progression. This article signifies the cumulative information about the role of WFA in modulating antitumor immunity and its potential in targeting prostate cancer. Hindawi 2021-08-25 /pmc/articles/PMC8413038/ /pubmed/34485538 http://dx.doi.org/10.1155/2021/9483433 Text en Copyright © 2021 Seema Dubey et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Dubey, Seema
Singh, Manohar
Nelson, Ariel
Karan, Dev
A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer
title A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer
title_full A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer
title_fullStr A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer
title_full_unstemmed A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer
title_short A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer
title_sort perspective on withania somnifera modulating antitumor immunity in targeting prostate cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413038/
https://www.ncbi.nlm.nih.gov/pubmed/34485538
http://dx.doi.org/10.1155/2021/9483433
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