Cargando…

Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone

BACKGROUND: Adult neurogenesis observed both in the subventricular zone (SVZ) and hippocampus may be regulated and modulated by several endogenous factors, xenobiotics and medications. Classical and atypical antipsychotic drugs are able to affect neuronal and glial cell proliferation in the rat brai...

Descripción completa

Detalles Bibliográficos
Autores principales: Skałbania, Jakub, Pałasz, Artur, Błaszczyk, Iwona, Suszka-Świtek, Aleksandra, Krzystanek, Marek, Tulcanaz, Karina Paola, Worthington, John J., Mordecka-Chamera, Kinga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413197/
https://www.ncbi.nlm.nih.gov/pubmed/33843023
http://dx.doi.org/10.1007/s43440-021-00259-7
_version_ 1783747610200244224
author Skałbania, Jakub
Pałasz, Artur
Błaszczyk, Iwona
Suszka-Świtek, Aleksandra
Krzystanek, Marek
Tulcanaz, Karina Paola
Worthington, John J.
Mordecka-Chamera, Kinga
author_facet Skałbania, Jakub
Pałasz, Artur
Błaszczyk, Iwona
Suszka-Świtek, Aleksandra
Krzystanek, Marek
Tulcanaz, Karina Paola
Worthington, John J.
Mordecka-Chamera, Kinga
author_sort Skałbania, Jakub
collection PubMed
description BACKGROUND: Adult neurogenesis observed both in the subventricular zone (SVZ) and hippocampus may be regulated and modulated by several endogenous factors, xenobiotics and medications. Classical and atypical antipsychotic drugs are able to affect neuronal and glial cell proliferation in the rat brain. The main purpose of this structural study was to determine whether chronic chlorpromazine treatment affects adult neurogenesis in the canonical sites of the rat brain. At present, the clinical application of chlorpromazine is rather limited; however, it may still represent an important model in basic neuropharmacological and toxicological studies. METHODS: The number of neural progenitors and immature neurons was enumerated using immunofluorescent detection of Sox2, Musashi1 and doublecortin (DCX) expression within SVZ. RESULTS: Chlorpromazine has a depressive effect on the early phase of adult neurogenesis in the rat subventricular zone (SVZ), as the mean number of Sox-2 immunoexpressing cells decreased following treatment. CONCLUSION: Collectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progenitor cell formation in the rat SVZ and may affect rostral migratory stream formation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s43440-021-00259-7.
format Online
Article
Text
id pubmed-8413197
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-84131972021-09-22 Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone Skałbania, Jakub Pałasz, Artur Błaszczyk, Iwona Suszka-Świtek, Aleksandra Krzystanek, Marek Tulcanaz, Karina Paola Worthington, John J. Mordecka-Chamera, Kinga Pharmacol Rep Special Issue: Short Communication BACKGROUND: Adult neurogenesis observed both in the subventricular zone (SVZ) and hippocampus may be regulated and modulated by several endogenous factors, xenobiotics and medications. Classical and atypical antipsychotic drugs are able to affect neuronal and glial cell proliferation in the rat brain. The main purpose of this structural study was to determine whether chronic chlorpromazine treatment affects adult neurogenesis in the canonical sites of the rat brain. At present, the clinical application of chlorpromazine is rather limited; however, it may still represent an important model in basic neuropharmacological and toxicological studies. METHODS: The number of neural progenitors and immature neurons was enumerated using immunofluorescent detection of Sox2, Musashi1 and doublecortin (DCX) expression within SVZ. RESULTS: Chlorpromazine has a depressive effect on the early phase of adult neurogenesis in the rat subventricular zone (SVZ), as the mean number of Sox-2 immunoexpressing cells decreased following treatment. CONCLUSION: Collectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progenitor cell formation in the rat SVZ and may affect rostral migratory stream formation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s43440-021-00259-7. Springer International Publishing 2021-04-12 2021 /pmc/articles/PMC8413197/ /pubmed/33843023 http://dx.doi.org/10.1007/s43440-021-00259-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Special Issue: Short Communication
Skałbania, Jakub
Pałasz, Artur
Błaszczyk, Iwona
Suszka-Świtek, Aleksandra
Krzystanek, Marek
Tulcanaz, Karina Paola
Worthington, John J.
Mordecka-Chamera, Kinga
Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone
title Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone
title_full Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone
title_fullStr Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone
title_full_unstemmed Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone
title_short Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone
title_sort chlorpromazine affects the numbers of sox-2, musashi1 and dcx-expressing cells in the rat brain subventricular zone
topic Special Issue: Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413197/
https://www.ncbi.nlm.nih.gov/pubmed/33843023
http://dx.doi.org/10.1007/s43440-021-00259-7
work_keys_str_mv AT skałbaniajakub chlorpromazineaffectsthenumbersofsox2musashi1anddcxexpressingcellsintheratbrainsubventricularzone
AT pałaszartur chlorpromazineaffectsthenumbersofsox2musashi1anddcxexpressingcellsintheratbrainsubventricularzone
AT błaszczykiwona chlorpromazineaffectsthenumbersofsox2musashi1anddcxexpressingcellsintheratbrainsubventricularzone
AT suszkaswitekaleksandra chlorpromazineaffectsthenumbersofsox2musashi1anddcxexpressingcellsintheratbrainsubventricularzone
AT krzystanekmarek chlorpromazineaffectsthenumbersofsox2musashi1anddcxexpressingcellsintheratbrainsubventricularzone
AT tulcanazkarinapaola chlorpromazineaffectsthenumbersofsox2musashi1anddcxexpressingcellsintheratbrainsubventricularzone
AT worthingtonjohnj chlorpromazineaffectsthenumbersofsox2musashi1anddcxexpressingcellsintheratbrainsubventricularzone
AT mordeckachamerakinga chlorpromazineaffectsthenumbersofsox2musashi1anddcxexpressingcellsintheratbrainsubventricularzone