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Apalutamide‐associated skin rash in patients with prostate cancer: Histological evaluation by skin biopsy
INTRODUCTION: Apalutamide‐associated skin rash is a more common adverse event in the Japanese population than in the global population. However, its mechanism remains elusive, and limited histopathological information hampers further understanding. CASE PRESENTATION: Case 1: a 71‐year‐old man with m...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413224/ https://www.ncbi.nlm.nih.gov/pubmed/34497989 http://dx.doi.org/10.1002/iju5.12331 |
Sumario: | INTRODUCTION: Apalutamide‐associated skin rash is a more common adverse event in the Japanese population than in the global population. However, its mechanism remains elusive, and limited histopathological information hampers further understanding. CASE PRESENTATION: Case 1: a 71‐year‐old man with metastatic castration‐sensitive prostate cancer developed a skin rash after 70 days of apalutamide treatment. Case 2: a 71‐year‐old man with non‐metastatic castration‐resistant prostate cancer developed a skin rash after 71 days of apalutamide treatment. In both cases, the skin rash presented as a slightly exudative erythema. The histology showed spongiosis of the epidermis and perivascular and interstitial infiltration of lymphocytes and eosinophils in the upper dermis without necrotic keratinocytes. CONCLUSION: Apalutamide‐induced skin rashes can involve an eczematous reaction clinically and histologically. |
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