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Protein disulphide isomerase (PDI) is protective against amyotrophic lateral sclerosis (ALS)-related mutant Fused in Sarcoma (FUS) in in vitro models

Mutations in Fused in Sarcoma (FUS) are present in familial and sporadic cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). FUS is localised in the nucleus where it has important functions in DNA repair. However, in ALS/FTD, mutant FUS mislocalises from the nucleus to th...

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Detalles Bibliográficos
Autores principales:	Parakh, S., Perri, E. R., Vidal, M., Sultana, J., Shadfar, S., Mehta, P., Konopka, A., Thomas, C. J., Spencer, D. M., Atkin, J. D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413276/ https://www.ncbi.nlm.nih.gov/pubmed/34475430 http://dx.doi.org/10.1038/s41598-021-96181-2

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