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Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma
The aim of the present study was to examine the conditions, characteristics, and risk factors of level IIb lymph node metastases in oral squamous cell carcinoma and to formulate surgical criteria for level IIb lymph node dissection. We analyzed clinical and pathological records for 541 oral squamous...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413325/ https://www.ncbi.nlm.nih.gov/pubmed/34475441 http://dx.doi.org/10.1038/s41598-021-96827-1 |
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author | Yang, Hyunwoo Son, Nak-Hoon Lee, Sung Hwa Kim, Dongwook Kim, Hyung Jun Cha, In-ho Nam, Woong |
author_facet | Yang, Hyunwoo Son, Nak-Hoon Lee, Sung Hwa Kim, Dongwook Kim, Hyung Jun Cha, In-ho Nam, Woong |
author_sort | Yang, Hyunwoo |
collection | PubMed |
description | The aim of the present study was to examine the conditions, characteristics, and risk factors of level IIb lymph node metastases in oral squamous cell carcinoma and to formulate surgical criteria for level IIb lymph node dissection. We analyzed clinical and pathological records for 541 oral squamous carcinoma patients in relation to level IIb metastasis. Univariate and multivariate analyses were performed to detect risk factors for level IIb lymph node metastasis; a predictive model was built based on multivariate analysis and tested in a validation group. Univariate and multivariate analyses using the training group indicated that level IIa metastasis and Lymphovascular permeation (LVP) were two independent risk factors for level IIb lymph node metastasis. This model was built and tested in a validation group, the area under the curve being 0.697 (P < .0.001). The model’s sensitivity was 66.7% and specificity was 77.4%. Nomogram incorporating validated variables was developed for level IIb metastasis prediction. Expected survival probabilites were analysed to specify significance of model's variable on patients’ overall survival and recurrence. Level IIb dissection should be performed in patients with level IIa metastasis and LVP. However, thorough consideration of the oncologic safety of omitting level IIb dissection is compulsory. |
format | Online Article Text |
id | pubmed-8413325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84133252021-09-07 Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma Yang, Hyunwoo Son, Nak-Hoon Lee, Sung Hwa Kim, Dongwook Kim, Hyung Jun Cha, In-ho Nam, Woong Sci Rep Article The aim of the present study was to examine the conditions, characteristics, and risk factors of level IIb lymph node metastases in oral squamous cell carcinoma and to formulate surgical criteria for level IIb lymph node dissection. We analyzed clinical and pathological records for 541 oral squamous carcinoma patients in relation to level IIb metastasis. Univariate and multivariate analyses were performed to detect risk factors for level IIb lymph node metastasis; a predictive model was built based on multivariate analysis and tested in a validation group. Univariate and multivariate analyses using the training group indicated that level IIa metastasis and Lymphovascular permeation (LVP) were two independent risk factors for level IIb lymph node metastasis. This model was built and tested in a validation group, the area under the curve being 0.697 (P < .0.001). The model’s sensitivity was 66.7% and specificity was 77.4%. Nomogram incorporating validated variables was developed for level IIb metastasis prediction. Expected survival probabilites were analysed to specify significance of model's variable on patients’ overall survival and recurrence. Level IIb dissection should be performed in patients with level IIa metastasis and LVP. However, thorough consideration of the oncologic safety of omitting level IIb dissection is compulsory. Nature Publishing Group UK 2021-09-02 /pmc/articles/PMC8413325/ /pubmed/34475441 http://dx.doi.org/10.1038/s41598-021-96827-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Yang, Hyunwoo Son, Nak-Hoon Lee, Sung Hwa Kim, Dongwook Kim, Hyung Jun Cha, In-ho Nam, Woong Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma |
title | Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma |
title_full | Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma |
title_fullStr | Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma |
title_full_unstemmed | Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma |
title_short | Predictive modelling of level IIb lymph node metastasis in oral squamous cell carcinoma |
title_sort | predictive modelling of level iib lymph node metastasis in oral squamous cell carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413325/ https://www.ncbi.nlm.nih.gov/pubmed/34475441 http://dx.doi.org/10.1038/s41598-021-96827-1 |
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