Essential role for paxillin tyrosine phosphorylation in LPS-induced mitochondrial fission, ROS generation and lung endothelial barrier loss

We have shown that both reactive oxygen species (ROS) and paxillin tyrosine phosphorylation regulate LPS-induced human lung endothelial permeability. Mitochondrial ROS (mtROS) is known to increase endothelial cell (EC) permeability which requires dynamic change in mitochondrial morphology, events th...

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Detalles Bibliográficos
Autores principales: Fu, Panfeng, Epshtein, Yulia, Ramchandran, Ramaswamy, Mascarenhas, Joseph B., Cress, Anne E., Jacobson, Jeffrey, Garcia, Joe G. N., Natarajan, Viswanathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413352/
https://www.ncbi.nlm.nih.gov/pubmed/34475475
http://dx.doi.org/10.1038/s41598-021-97006-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413352/
https://www.ncbi.nlm.nih.gov/pubmed/34475475
http://dx.doi.org/10.1038/s41598-021-97006-y

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