Cargando…

Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care

Diabetes mellitus (DM) and arterial hypertension (AH) are the two main clinical conditions related to Chronic Kidney Disease (CKD); disease also identify by the levels of low-grade albuminuria (LGA). Few studies have simultaneously investigated the associations of glycated hemoglobin (HbA1c) and fas...

Descripción completa

Detalles Bibliográficos
Autores principales: de Resende, Matheus Augusto Soares, Ferreira, Emily de Souza, Dias, Heloísa Helena, Santos, Daniel Souza, Batistelli, Clara Regina Santos, Borges, Luiza Delazari, Comini, Luma de Oliveira, Moreira, Tiago Ricardo, da Costa, Glauce Dias, da Silva, Eunice Ferreira, da Silva, Rodrigo Gomes, Cotta, Rosângela Minardi Mitre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413384/
https://www.ncbi.nlm.nih.gov/pubmed/34475440
http://dx.doi.org/10.1038/s41598-021-96652-6
_version_ 1783747652756701184
author de Resende, Matheus Augusto Soares
Ferreira, Emily de Souza
Dias, Heloísa Helena
Santos, Daniel Souza
Batistelli, Clara Regina Santos
Borges, Luiza Delazari
Comini, Luma de Oliveira
Moreira, Tiago Ricardo
da Costa, Glauce Dias
da Silva, Eunice Ferreira
da Silva, Rodrigo Gomes
Cotta, Rosângela Minardi Mitre
author_facet de Resende, Matheus Augusto Soares
Ferreira, Emily de Souza
Dias, Heloísa Helena
Santos, Daniel Souza
Batistelli, Clara Regina Santos
Borges, Luiza Delazari
Comini, Luma de Oliveira
Moreira, Tiago Ricardo
da Costa, Glauce Dias
da Silva, Eunice Ferreira
da Silva, Rodrigo Gomes
Cotta, Rosângela Minardi Mitre
author_sort de Resende, Matheus Augusto Soares
collection PubMed
description Diabetes mellitus (DM) and arterial hypertension (AH) are the two main clinical conditions related to Chronic Kidney Disease (CKD); disease also identify by the levels of low-grade albuminuria (LGA). Few studies have simultaneously investigated the associations of glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) with LGA. Our study aimed to investigate and compare the association of HbA1c and FPG with the probability of LGA in adult and elderly individuals with DM and AH, within the scope of Primary Health Care (PHC). Cross-sectional study involving 737 Brazilians individuals previously diagnosed with hypertension and/or diabetes. Tests for HbA1c, FPG and LGA were performed. LGA was defined as the highest quartile of albumin urinary (≥ 13 mg/g) among individuals with urinary LGA < 30 mg / g. A significant increase in the prevalence of LGA was found with increasing levels of HbA1c (p < 0.001). There was a significant association of HbA1c with LGA (p < 0.001) and increased probability of LGA for participants with HbA1c ≥ 6.5% compared to those with Hba1c < 5.7% (OR [95% CI]: 2.43 [1.32–4.46], p < 0.05), after adjusting for confounding factors, except when adjusted for FPG (p = 0.379 and p = 0.359, respectively). HbA1c and FPG were significantly associated in a collinear manner with an increased probability of LGA in adult and elderly individuals with DM and AH.
format Online
Article
Text
id pubmed-8413384
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-84133842021-09-07 Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care de Resende, Matheus Augusto Soares Ferreira, Emily de Souza Dias, Heloísa Helena Santos, Daniel Souza Batistelli, Clara Regina Santos Borges, Luiza Delazari Comini, Luma de Oliveira Moreira, Tiago Ricardo da Costa, Glauce Dias da Silva, Eunice Ferreira da Silva, Rodrigo Gomes Cotta, Rosângela Minardi Mitre Sci Rep Article Diabetes mellitus (DM) and arterial hypertension (AH) are the two main clinical conditions related to Chronic Kidney Disease (CKD); disease also identify by the levels of low-grade albuminuria (LGA). Few studies have simultaneously investigated the associations of glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) with LGA. Our study aimed to investigate and compare the association of HbA1c and FPG with the probability of LGA in adult and elderly individuals with DM and AH, within the scope of Primary Health Care (PHC). Cross-sectional study involving 737 Brazilians individuals previously diagnosed with hypertension and/or diabetes. Tests for HbA1c, FPG and LGA were performed. LGA was defined as the highest quartile of albumin urinary (≥ 13 mg/g) among individuals with urinary LGA < 30 mg / g. A significant increase in the prevalence of LGA was found with increasing levels of HbA1c (p < 0.001). There was a significant association of HbA1c with LGA (p < 0.001) and increased probability of LGA for participants with HbA1c ≥ 6.5% compared to those with Hba1c < 5.7% (OR [95% CI]: 2.43 [1.32–4.46], p < 0.05), after adjusting for confounding factors, except when adjusted for FPG (p = 0.379 and p = 0.359, respectively). HbA1c and FPG were significantly associated in a collinear manner with an increased probability of LGA in adult and elderly individuals with DM and AH. Nature Publishing Group UK 2021-09-02 /pmc/articles/PMC8413384/ /pubmed/34475440 http://dx.doi.org/10.1038/s41598-021-96652-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
de Resende, Matheus Augusto Soares
Ferreira, Emily de Souza
Dias, Heloísa Helena
Santos, Daniel Souza
Batistelli, Clara Regina Santos
Borges, Luiza Delazari
Comini, Luma de Oliveira
Moreira, Tiago Ricardo
da Costa, Glauce Dias
da Silva, Eunice Ferreira
da Silva, Rodrigo Gomes
Cotta, Rosângela Minardi Mitre
Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care
title Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care
title_full Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care
title_fullStr Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care
title_full_unstemmed Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care
title_short Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care
title_sort low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by primary health care
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413384/
https://www.ncbi.nlm.nih.gov/pubmed/34475440
http://dx.doi.org/10.1038/s41598-021-96652-6
work_keys_str_mv AT deresendematheusaugustosoares lowgradealbuminuriainadultandelderlyindividualswithdiabetesmellitusandarterialhypertensionaccompaniedbyprimaryhealthcare
AT ferreiraemilydesouza lowgradealbuminuriainadultandelderlyindividualswithdiabetesmellitusandarterialhypertensionaccompaniedbyprimaryhealthcare
AT diasheloisahelena lowgradealbuminuriainadultandelderlyindividualswithdiabetesmellitusandarterialhypertensionaccompaniedbyprimaryhealthcare
AT santosdanielsouza lowgradealbuminuriainadultandelderlyindividualswithdiabetesmellitusandarterialhypertensionaccompaniedbyprimaryhealthcare
AT batistelliclarareginasantos lowgradealbuminuriainadultandelderlyindividualswithdiabetesmellitusandarterialhypertensionaccompaniedbyprimaryhealthcare
AT borgesluizadelazari lowgradealbuminuriainadultandelderlyindividualswithdiabetesmellitusandarterialhypertensionaccompaniedbyprimaryhealthcare
AT cominilumadeoliveira lowgradealbuminuriainadultandelderlyindividualswithdiabetesmellitusandarterialhypertensionaccompaniedbyprimaryhealthcare
AT moreiratiagoricardo lowgradealbuminuriainadultandelderlyindividualswithdiabetesmellitusandarterialhypertensionaccompaniedbyprimaryhealthcare
AT dacostaglaucedias lowgradealbuminuriainadultandelderlyindividualswithdiabetesmellitusandarterialhypertensionaccompaniedbyprimaryhealthcare
AT dasilvaeuniceferreira lowgradealbuminuriainadultandelderlyindividualswithdiabetesmellitusandarterialhypertensionaccompaniedbyprimaryhealthcare
AT dasilvarodrigogomes lowgradealbuminuriainadultandelderlyindividualswithdiabetesmellitusandarterialhypertensionaccompaniedbyprimaryhealthcare
AT cottarosangelaminardimitre lowgradealbuminuriainadultandelderlyindividualswithdiabetesmellitusandarterialhypertensionaccompaniedbyprimaryhealthcare