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Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care
Diabetes mellitus (DM) and arterial hypertension (AH) are the two main clinical conditions related to Chronic Kidney Disease (CKD); disease also identify by the levels of low-grade albuminuria (LGA). Few studies have simultaneously investigated the associations of glycated hemoglobin (HbA1c) and fas...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413384/ https://www.ncbi.nlm.nih.gov/pubmed/34475440 http://dx.doi.org/10.1038/s41598-021-96652-6 |
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author | de Resende, Matheus Augusto Soares Ferreira, Emily de Souza Dias, Heloísa Helena Santos, Daniel Souza Batistelli, Clara Regina Santos Borges, Luiza Delazari Comini, Luma de Oliveira Moreira, Tiago Ricardo da Costa, Glauce Dias da Silva, Eunice Ferreira da Silva, Rodrigo Gomes Cotta, Rosângela Minardi Mitre |
author_facet | de Resende, Matheus Augusto Soares Ferreira, Emily de Souza Dias, Heloísa Helena Santos, Daniel Souza Batistelli, Clara Regina Santos Borges, Luiza Delazari Comini, Luma de Oliveira Moreira, Tiago Ricardo da Costa, Glauce Dias da Silva, Eunice Ferreira da Silva, Rodrigo Gomes Cotta, Rosângela Minardi Mitre |
author_sort | de Resende, Matheus Augusto Soares |
collection | PubMed |
description | Diabetes mellitus (DM) and arterial hypertension (AH) are the two main clinical conditions related to Chronic Kidney Disease (CKD); disease also identify by the levels of low-grade albuminuria (LGA). Few studies have simultaneously investigated the associations of glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) with LGA. Our study aimed to investigate and compare the association of HbA1c and FPG with the probability of LGA in adult and elderly individuals with DM and AH, within the scope of Primary Health Care (PHC). Cross-sectional study involving 737 Brazilians individuals previously diagnosed with hypertension and/or diabetes. Tests for HbA1c, FPG and LGA were performed. LGA was defined as the highest quartile of albumin urinary (≥ 13 mg/g) among individuals with urinary LGA < 30 mg / g. A significant increase in the prevalence of LGA was found with increasing levels of HbA1c (p < 0.001). There was a significant association of HbA1c with LGA (p < 0.001) and increased probability of LGA for participants with HbA1c ≥ 6.5% compared to those with Hba1c < 5.7% (OR [95% CI]: 2.43 [1.32–4.46], p < 0.05), after adjusting for confounding factors, except when adjusted for FPG (p = 0.379 and p = 0.359, respectively). HbA1c and FPG were significantly associated in a collinear manner with an increased probability of LGA in adult and elderly individuals with DM and AH. |
format | Online Article Text |
id | pubmed-8413384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-84133842021-09-07 Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care de Resende, Matheus Augusto Soares Ferreira, Emily de Souza Dias, Heloísa Helena Santos, Daniel Souza Batistelli, Clara Regina Santos Borges, Luiza Delazari Comini, Luma de Oliveira Moreira, Tiago Ricardo da Costa, Glauce Dias da Silva, Eunice Ferreira da Silva, Rodrigo Gomes Cotta, Rosângela Minardi Mitre Sci Rep Article Diabetes mellitus (DM) and arterial hypertension (AH) are the two main clinical conditions related to Chronic Kidney Disease (CKD); disease also identify by the levels of low-grade albuminuria (LGA). Few studies have simultaneously investigated the associations of glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) with LGA. Our study aimed to investigate and compare the association of HbA1c and FPG with the probability of LGA in adult and elderly individuals with DM and AH, within the scope of Primary Health Care (PHC). Cross-sectional study involving 737 Brazilians individuals previously diagnosed with hypertension and/or diabetes. Tests for HbA1c, FPG and LGA were performed. LGA was defined as the highest quartile of albumin urinary (≥ 13 mg/g) among individuals with urinary LGA < 30 mg / g. A significant increase in the prevalence of LGA was found with increasing levels of HbA1c (p < 0.001). There was a significant association of HbA1c with LGA (p < 0.001) and increased probability of LGA for participants with HbA1c ≥ 6.5% compared to those with Hba1c < 5.7% (OR [95% CI]: 2.43 [1.32–4.46], p < 0.05), after adjusting for confounding factors, except when adjusted for FPG (p = 0.379 and p = 0.359, respectively). HbA1c and FPG were significantly associated in a collinear manner with an increased probability of LGA in adult and elderly individuals with DM and AH. Nature Publishing Group UK 2021-09-02 /pmc/articles/PMC8413384/ /pubmed/34475440 http://dx.doi.org/10.1038/s41598-021-96652-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article de Resende, Matheus Augusto Soares Ferreira, Emily de Souza Dias, Heloísa Helena Santos, Daniel Souza Batistelli, Clara Regina Santos Borges, Luiza Delazari Comini, Luma de Oliveira Moreira, Tiago Ricardo da Costa, Glauce Dias da Silva, Eunice Ferreira da Silva, Rodrigo Gomes Cotta, Rosângela Minardi Mitre Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care |
title | Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care |
title_full | Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care |
title_fullStr | Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care |
title_full_unstemmed | Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care |
title_short | Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care |
title_sort | low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by primary health care |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413384/ https://www.ncbi.nlm.nih.gov/pubmed/34475440 http://dx.doi.org/10.1038/s41598-021-96652-6 |
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