Cell reprogramming shapes the mitochondrial DNA landscape

Individual induced pluripotent stem cells (iPSCs) show considerable phenotypic heterogeneity, but the reasons for this are not fully understood. Comprehensively analysing the mitochondrial genome (mtDNA) in 146 iPSC and fibroblast lines from 151 donors, we show that most age-related fibroblast mtDNA...

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Detalles Bibliográficos
Autores principales: Wei, Wei, Gaffney, Daniel J., Chinnery, Patrick F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413449/
https://www.ncbi.nlm.nih.gov/pubmed/34475388
http://dx.doi.org/10.1038/s41467-021-25482-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413449/
https://www.ncbi.nlm.nih.gov/pubmed/34475388
http://dx.doi.org/10.1038/s41467-021-25482-x

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