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Fidelity, tolerability and safety of acute high-intensity interval training after hospitalisation for COVID-19: a randomised cross-over trial

Objectives. Many patients with COVID-19 suffer from persistent symptoms, many of which may potentially be reversed by high-intensity interval training (HIIT). Yet, the safety and tolerability of HIIT after COVID-19 is controversial. This study aimed to investigate the fidelity, tolerability and safe...

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Autores principales: Foged, Frederik, Rasmussen, Iben Elmerdahl, Bjørn Budde, Josephine, Rasmussen, Rasmus Syberg, Rasmussen, Villads, Lyngbæk, Mark, Jønck, Simon, Krogh-Madsen, Rikke, Lindegaard, Birgitte, Ried-Larsen, Mathias, Berg, Ronan Martin Griffin, Christensen, Regitse Højgaard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413475/
https://www.ncbi.nlm.nih.gov/pubmed/34493958
http://dx.doi.org/10.1136/bmjsem-2021-001156
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author Foged, Frederik
Rasmussen, Iben Elmerdahl
Bjørn Budde, Josephine
Rasmussen, Rasmus Syberg
Rasmussen, Villads
Lyngbæk, Mark
Jønck, Simon
Krogh-Madsen, Rikke
Lindegaard, Birgitte
Ried-Larsen, Mathias
Berg, Ronan Martin Griffin
Christensen, Regitse Højgaard
author_facet Foged, Frederik
Rasmussen, Iben Elmerdahl
Bjørn Budde, Josephine
Rasmussen, Rasmus Syberg
Rasmussen, Villads
Lyngbæk, Mark
Jønck, Simon
Krogh-Madsen, Rikke
Lindegaard, Birgitte
Ried-Larsen, Mathias
Berg, Ronan Martin Griffin
Christensen, Regitse Højgaard
author_sort Foged, Frederik
collection PubMed
description Objectives. Many patients with COVID-19 suffer from persistent symptoms, many of which may potentially be reversed by high-intensity interval training (HIIT). Yet, the safety and tolerability of HIIT after COVID-19 is controversial. This study aimed to investigate the fidelity, tolerability and safety of three different HIIT protocols in individuals that had recently been hospitalised due to COVID-19. Methods. The study was a randomised cross-over trial. We compared three supervised HIIT protocols (4×4, 6×1, 10-20-30) in 10 individuals recently discharged after hospitalisation for severe COVID-19. Each HIIT protocol had a duration of 38 min and was performed with a 1-week washout between them. Outcomes included adverse events, exercise training intensity and tolerability assessed by the Likert scale (1–10). Results. All 10 participants aged 61 (mean, SD 8) years (5 males) completed all three HIIT protocols with no adverse events. High intensities were achieved in all three protocols, although they differed in terms of time spent with a heart rate ≥85% of maximum (mean (SD); 4×4: 13.7 (6.4) min; 10-20-30: 12.1 (3.8) min; 6×1: 6.1 (5.6) min; p=0.03). The three protocols were all well tolerated with similar Likert scale scores (mean (SD); 4×4: 8 (2), 10-20-30: 8 (2), 6×1: 9 (2), p=0.72). Conclusion. Our findings indicate that recently hospitalised individuals for severe COVID-19 may safely tolerate acute bouts of supervised HIIT as per protocol. This warrants future studies testing the potential of regular HIIT as a rehabilitation strategy in this context.
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spelling pubmed-84134752021-09-03 Fidelity, tolerability and safety of acute high-intensity interval training after hospitalisation for COVID-19: a randomised cross-over trial Foged, Frederik Rasmussen, Iben Elmerdahl Bjørn Budde, Josephine Rasmussen, Rasmus Syberg Rasmussen, Villads Lyngbæk, Mark Jønck, Simon Krogh-Madsen, Rikke Lindegaard, Birgitte Ried-Larsen, Mathias Berg, Ronan Martin Griffin Christensen, Regitse Højgaard BMJ Open Sport Exerc Med Original Research Objectives. Many patients with COVID-19 suffer from persistent symptoms, many of which may potentially be reversed by high-intensity interval training (HIIT). Yet, the safety and tolerability of HIIT after COVID-19 is controversial. This study aimed to investigate the fidelity, tolerability and safety of three different HIIT protocols in individuals that had recently been hospitalised due to COVID-19. Methods. The study was a randomised cross-over trial. We compared three supervised HIIT protocols (4×4, 6×1, 10-20-30) in 10 individuals recently discharged after hospitalisation for severe COVID-19. Each HIIT protocol had a duration of 38 min and was performed with a 1-week washout between them. Outcomes included adverse events, exercise training intensity and tolerability assessed by the Likert scale (1–10). Results. All 10 participants aged 61 (mean, SD 8) years (5 males) completed all three HIIT protocols with no adverse events. High intensities were achieved in all three protocols, although they differed in terms of time spent with a heart rate ≥85% of maximum (mean (SD); 4×4: 13.7 (6.4) min; 10-20-30: 12.1 (3.8) min; 6×1: 6.1 (5.6) min; p=0.03). The three protocols were all well tolerated with similar Likert scale scores (mean (SD); 4×4: 8 (2), 10-20-30: 8 (2), 6×1: 9 (2), p=0.72). Conclusion. Our findings indicate that recently hospitalised individuals for severe COVID-19 may safely tolerate acute bouts of supervised HIIT as per protocol. This warrants future studies testing the potential of regular HIIT as a rehabilitation strategy in this context. BMJ Publishing Group 2021-09-01 /pmc/articles/PMC8413475/ /pubmed/34493958 http://dx.doi.org/10.1136/bmjsem-2021-001156 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Original Research
Foged, Frederik
Rasmussen, Iben Elmerdahl
Bjørn Budde, Josephine
Rasmussen, Rasmus Syberg
Rasmussen, Villads
Lyngbæk, Mark
Jønck, Simon
Krogh-Madsen, Rikke
Lindegaard, Birgitte
Ried-Larsen, Mathias
Berg, Ronan Martin Griffin
Christensen, Regitse Højgaard
Fidelity, tolerability and safety of acute high-intensity interval training after hospitalisation for COVID-19: a randomised cross-over trial
title Fidelity, tolerability and safety of acute high-intensity interval training after hospitalisation for COVID-19: a randomised cross-over trial
title_full Fidelity, tolerability and safety of acute high-intensity interval training after hospitalisation for COVID-19: a randomised cross-over trial
title_fullStr Fidelity, tolerability and safety of acute high-intensity interval training after hospitalisation for COVID-19: a randomised cross-over trial
title_full_unstemmed Fidelity, tolerability and safety of acute high-intensity interval training after hospitalisation for COVID-19: a randomised cross-over trial
title_short Fidelity, tolerability and safety of acute high-intensity interval training after hospitalisation for COVID-19: a randomised cross-over trial
title_sort fidelity, tolerability and safety of acute high-intensity interval training after hospitalisation for covid-19: a randomised cross-over trial
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413475/
https://www.ncbi.nlm.nih.gov/pubmed/34493958
http://dx.doi.org/10.1136/bmjsem-2021-001156
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