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COVID-19 in a patient with sporadic lymphangioleiomyomatosis awaiting lung transplantation
Coronavirus disease 2019 (COVID-19) is an emerging viral disease with a mortality that depends on the individual's condition. Underlying comorbidities are major risk factors for COVID-19-related morbidity and mortality. However, information regarding the clinical course of COVID-19 in patients...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413486/ https://www.ncbi.nlm.nih.gov/pubmed/34493971 http://dx.doi.org/10.1016/j.rmcr.2021.101505 |
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author | Noda, Yoshimi Shiroyama, Takayuki Amiya, Saori Adachi, Yuichi Enomoto, Takatoshi Hara, Reina Niitsu, Takayuki Miyake, Kotaro Hirata, Haruhiko Takeda, Yoshito Kumanogoh, Atsushi |
author_facet | Noda, Yoshimi Shiroyama, Takayuki Amiya, Saori Adachi, Yuichi Enomoto, Takatoshi Hara, Reina Niitsu, Takayuki Miyake, Kotaro Hirata, Haruhiko Takeda, Yoshito Kumanogoh, Atsushi |
author_sort | Noda, Yoshimi |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19) is an emerging viral disease with a mortality that depends on the individual's condition. Underlying comorbidities are major risk factors for COVID-19-related morbidity and mortality. However, information regarding the clinical course of COVID-19 in patients with rare respiratory system diseases is lacking. Here, we present a case of severe COVID-19 in a patient with advanced sporadic lymphangioleiomyomatosis (LAM) who was awaiting lung transplantation. She experienced a marked worsening of her respiratory status despite the limited size of the infiltrations seen on chest computed tomography. She responded to treatment with dexamethasone and remdesivir, and did not require mechanical ventilation. She recovered her pre-COVID-19 respiratory function. This case illustrates that patients with severe lung parenchymal destruction due to advanced LAM are at risk of worsening hypoxemia, but may not have a bad outcome if managed appropriately. Prevention and early diagnosis of COVID-19 are crucial in patients with advanced LAM. Future studies are needed to improve understanding of the clinical features and optimal treatment of COVID-19 in patients with LAM. |
format | Online Article Text |
id | pubmed-8413486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-84134862021-09-03 COVID-19 in a patient with sporadic lymphangioleiomyomatosis awaiting lung transplantation Noda, Yoshimi Shiroyama, Takayuki Amiya, Saori Adachi, Yuichi Enomoto, Takatoshi Hara, Reina Niitsu, Takayuki Miyake, Kotaro Hirata, Haruhiko Takeda, Yoshito Kumanogoh, Atsushi Respir Med Case Rep Case Report Coronavirus disease 2019 (COVID-19) is an emerging viral disease with a mortality that depends on the individual's condition. Underlying comorbidities are major risk factors for COVID-19-related morbidity and mortality. However, information regarding the clinical course of COVID-19 in patients with rare respiratory system diseases is lacking. Here, we present a case of severe COVID-19 in a patient with advanced sporadic lymphangioleiomyomatosis (LAM) who was awaiting lung transplantation. She experienced a marked worsening of her respiratory status despite the limited size of the infiltrations seen on chest computed tomography. She responded to treatment with dexamethasone and remdesivir, and did not require mechanical ventilation. She recovered her pre-COVID-19 respiratory function. This case illustrates that patients with severe lung parenchymal destruction due to advanced LAM are at risk of worsening hypoxemia, but may not have a bad outcome if managed appropriately. Prevention and early diagnosis of COVID-19 are crucial in patients with advanced LAM. Future studies are needed to improve understanding of the clinical features and optimal treatment of COVID-19 in patients with LAM. Elsevier 2021-09-03 /pmc/articles/PMC8413486/ /pubmed/34493971 http://dx.doi.org/10.1016/j.rmcr.2021.101505 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Noda, Yoshimi Shiroyama, Takayuki Amiya, Saori Adachi, Yuichi Enomoto, Takatoshi Hara, Reina Niitsu, Takayuki Miyake, Kotaro Hirata, Haruhiko Takeda, Yoshito Kumanogoh, Atsushi COVID-19 in a patient with sporadic lymphangioleiomyomatosis awaiting lung transplantation |
title | COVID-19 in a patient with sporadic lymphangioleiomyomatosis awaiting lung transplantation |
title_full | COVID-19 in a patient with sporadic lymphangioleiomyomatosis awaiting lung transplantation |
title_fullStr | COVID-19 in a patient with sporadic lymphangioleiomyomatosis awaiting lung transplantation |
title_full_unstemmed | COVID-19 in a patient with sporadic lymphangioleiomyomatosis awaiting lung transplantation |
title_short | COVID-19 in a patient with sporadic lymphangioleiomyomatosis awaiting lung transplantation |
title_sort | covid-19 in a patient with sporadic lymphangioleiomyomatosis awaiting lung transplantation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413486/ https://www.ncbi.nlm.nih.gov/pubmed/34493971 http://dx.doi.org/10.1016/j.rmcr.2021.101505 |
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