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Genome-wide activation screens to increase adeno-associated virus production

We describe a genome-wide screening strategy to identify target genes whose modulation increases the capacity of a cell to produce recombinant adeno-associated viral (AAV) vector. Specifically, a single-guide RNA (sgRNA) library for a CRISPR-based genome-wide transcriptional activation screen was in...

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Detalles Bibliográficos
Autores principales:	Barnes, Christopher R., Lee, Hyuncheol, Ojala, David S., Lewis, Kazuomori K., Limsirichai, Prajit, Schaffer, David V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413672/ https://www.ncbi.nlm.nih.gov/pubmed/34513296 http://dx.doi.org/10.1016/j.omtn.2021.06.026

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