Regulatory roles of tRNA-derived RNA fragments in human pathophysiology

Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are the second most abundant type of RNA in the cell. Advancement in deep-sequencing technologies have revealed the presence of abundant expression of functional tRNA-derived RNA fragments (tRFs). They are either generated...

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Autores principales: Pandey, Kush Kumar, Madhry, Deeksha, Ravi Kumar, Y.S., Malvankar, Shivani, Sapra, Leena, Srivastava, Rupesh K., Bhattacharyya, Sankar, Verma, Bhupendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413677/
https://www.ncbi.nlm.nih.gov/pubmed/34513302
http://dx.doi.org/10.1016/j.omtn.2021.06.023
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author Pandey, Kush Kumar
Madhry, Deeksha
Ravi Kumar, Y.S.
Malvankar, Shivani
Sapra, Leena
Srivastava, Rupesh K.
Bhattacharyya, Sankar
Verma, Bhupendra
author_facet Pandey, Kush Kumar
Madhry, Deeksha
Ravi Kumar, Y.S.
Malvankar, Shivani
Sapra, Leena
Srivastava, Rupesh K.
Bhattacharyya, Sankar
Verma, Bhupendra
author_sort Pandey, Kush Kumar
collection PubMed
description Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are the second most abundant type of RNA in the cell. Advancement in deep-sequencing technologies have revealed the presence of abundant expression of functional tRNA-derived RNA fragments (tRFs). They are either generated from precursor (pre-)tRNA or mature tRNA. They have been found to play crucial regulatory roles during different pathological conditions. Herein, we briefly summarize the discovery and recent advances in deciphering the regulatory role played by tRFs in the pathophysiology of different human diseases.
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spelling pubmed-84136772021-09-10 Regulatory roles of tRNA-derived RNA fragments in human pathophysiology Pandey, Kush Kumar Madhry, Deeksha Ravi Kumar, Y.S. Malvankar, Shivani Sapra, Leena Srivastava, Rupesh K. Bhattacharyya, Sankar Verma, Bhupendra Mol Ther Nucleic Acids Review Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are the second most abundant type of RNA in the cell. Advancement in deep-sequencing technologies have revealed the presence of abundant expression of functional tRNA-derived RNA fragments (tRFs). They are either generated from precursor (pre-)tRNA or mature tRNA. They have been found to play crucial regulatory roles during different pathological conditions. Herein, we briefly summarize the discovery and recent advances in deciphering the regulatory role played by tRFs in the pathophysiology of different human diseases. American Society of Gene & Cell Therapy 2021-07-02 /pmc/articles/PMC8413677/ /pubmed/34513302 http://dx.doi.org/10.1016/j.omtn.2021.06.023 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pandey, Kush Kumar
Madhry, Deeksha
Ravi Kumar, Y.S.
Malvankar, Shivani
Sapra, Leena
Srivastava, Rupesh K.
Bhattacharyya, Sankar
Verma, Bhupendra
Regulatory roles of tRNA-derived RNA fragments in human pathophysiology
title Regulatory roles of tRNA-derived RNA fragments in human pathophysiology
title_full Regulatory roles of tRNA-derived RNA fragments in human pathophysiology
title_fullStr Regulatory roles of tRNA-derived RNA fragments in human pathophysiology
title_full_unstemmed Regulatory roles of tRNA-derived RNA fragments in human pathophysiology
title_short Regulatory roles of tRNA-derived RNA fragments in human pathophysiology
title_sort regulatory roles of trna-derived rna fragments in human pathophysiology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413677/
https://www.ncbi.nlm.nih.gov/pubmed/34513302
http://dx.doi.org/10.1016/j.omtn.2021.06.023
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