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Global efficiency of the motor network is decreased in Parkinson's disease in comparison with essential tremor and healthy controls

BACKGROUND: Graph theory (GT) is a mathematical field that analyses complex networks that can be applied to neuroimaging to quantify brain's functional systems in Parkinson's disease (PD) and essential tremor (ET). OBJECTIVES: To evaluate the functional connectivity (FC) measured by the gl...

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Autores principales: Novaes, Natalia Pelizari, Balardin, Joana Bisol, Hirata, Fabiana Campos, Melo, Luciano, Amaro, Edson, Barbosa, Egberto Reis, Sato, João Ricardo, Cardoso, Ellison Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413813/
https://www.ncbi.nlm.nih.gov/pubmed/34302446
http://dx.doi.org/10.1002/brb3.2178
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author Novaes, Natalia Pelizari
Balardin, Joana Bisol
Hirata, Fabiana Campos
Melo, Luciano
Amaro, Edson
Barbosa, Egberto Reis
Sato, João Ricardo
Cardoso, Ellison Fernando
author_facet Novaes, Natalia Pelizari
Balardin, Joana Bisol
Hirata, Fabiana Campos
Melo, Luciano
Amaro, Edson
Barbosa, Egberto Reis
Sato, João Ricardo
Cardoso, Ellison Fernando
author_sort Novaes, Natalia Pelizari
collection PubMed
description BACKGROUND: Graph theory (GT) is a mathematical field that analyses complex networks that can be applied to neuroimaging to quantify brain's functional systems in Parkinson's disease (PD) and essential tremor (ET). OBJECTIVES: To evaluate the functional connectivity (FC) measured by the global efficiency (GE) of the motor network in PD and compare it to ET and healthy controls (HC), and correlate it to clinical parameters. METHODS: 103 subjects (54PD, 18ET, 31HC) were submitted to structural and functional MRI. A network was designed with regions of interest (ROIs) involved in motor function, and GT was applied to determine its GE. Clinical parameters were analyzed as covariates to estimate the impact of disease severity and medication on GE. RESULTS: GE of the motor circuit was reduced in PD in comparison with HC (p .042). Areas that most contributed to it were left supplementary motor area (SMA) and bilateral postcentral gyrus. Tremor scores correlated positively with GE of the motor network in PD subgroups. For ET, there was an increase in the connectivity of the anterior cerebellar network to the other ROIs of the motor circuit in comparison with PD. CONCLUSIONS: FC measured by the GE of the motor network is diminished in PD in comparison with HC, especially due to decreased connectivity of left SMA and bilateral postcentral gyrus. This finding supports the theory that there is a global impairment of the motor network in PD, and it does not affect just the basal ganglia, but also areas associated with movement modulation. The ET group presented an increased connectivity of the anterior cerebellar network to the other ROIs of the motor circuit when compared to PD, which reinforces what it is known about its role in this pathology.
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spelling pubmed-84138132021-09-07 Global efficiency of the motor network is decreased in Parkinson's disease in comparison with essential tremor and healthy controls Novaes, Natalia Pelizari Balardin, Joana Bisol Hirata, Fabiana Campos Melo, Luciano Amaro, Edson Barbosa, Egberto Reis Sato, João Ricardo Cardoso, Ellison Fernando Brain Behav Original Research BACKGROUND: Graph theory (GT) is a mathematical field that analyses complex networks that can be applied to neuroimaging to quantify brain's functional systems in Parkinson's disease (PD) and essential tremor (ET). OBJECTIVES: To evaluate the functional connectivity (FC) measured by the global efficiency (GE) of the motor network in PD and compare it to ET and healthy controls (HC), and correlate it to clinical parameters. METHODS: 103 subjects (54PD, 18ET, 31HC) were submitted to structural and functional MRI. A network was designed with regions of interest (ROIs) involved in motor function, and GT was applied to determine its GE. Clinical parameters were analyzed as covariates to estimate the impact of disease severity and medication on GE. RESULTS: GE of the motor circuit was reduced in PD in comparison with HC (p .042). Areas that most contributed to it were left supplementary motor area (SMA) and bilateral postcentral gyrus. Tremor scores correlated positively with GE of the motor network in PD subgroups. For ET, there was an increase in the connectivity of the anterior cerebellar network to the other ROIs of the motor circuit in comparison with PD. CONCLUSIONS: FC measured by the GE of the motor network is diminished in PD in comparison with HC, especially due to decreased connectivity of left SMA and bilateral postcentral gyrus. This finding supports the theory that there is a global impairment of the motor network in PD, and it does not affect just the basal ganglia, but also areas associated with movement modulation. The ET group presented an increased connectivity of the anterior cerebellar network to the other ROIs of the motor circuit when compared to PD, which reinforces what it is known about its role in this pathology. John Wiley and Sons Inc. 2021-07-24 /pmc/articles/PMC8413813/ /pubmed/34302446 http://dx.doi.org/10.1002/brb3.2178 Text en © 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Novaes, Natalia Pelizari
Balardin, Joana Bisol
Hirata, Fabiana Campos
Melo, Luciano
Amaro, Edson
Barbosa, Egberto Reis
Sato, João Ricardo
Cardoso, Ellison Fernando
Global efficiency of the motor network is decreased in Parkinson's disease in comparison with essential tremor and healthy controls
title Global efficiency of the motor network is decreased in Parkinson's disease in comparison with essential tremor and healthy controls
title_full Global efficiency of the motor network is decreased in Parkinson's disease in comparison with essential tremor and healthy controls
title_fullStr Global efficiency of the motor network is decreased in Parkinson's disease in comparison with essential tremor and healthy controls
title_full_unstemmed Global efficiency of the motor network is decreased in Parkinson's disease in comparison with essential tremor and healthy controls
title_short Global efficiency of the motor network is decreased in Parkinson's disease in comparison with essential tremor and healthy controls
title_sort global efficiency of the motor network is decreased in parkinson's disease in comparison with essential tremor and healthy controls
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413813/
https://www.ncbi.nlm.nih.gov/pubmed/34302446
http://dx.doi.org/10.1002/brb3.2178
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