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Effects of seizure burden on structural global brain networks in patients with unilateral hippocampal sclerosis
BACKGROUND AND PURPOSE: Temporal lobe epilepsy secondary to hippocampal sclerosis is related to epileptogenic networks rather than a focal epileptogenic source. Graph‐theoretical gray and white matter networks may help to identify alterations within these epileptogenic networks. METHODS: Twenty‐seve...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413824/ https://www.ncbi.nlm.nih.gov/pubmed/34105906 http://dx.doi.org/10.1002/brb3.2237 |
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author | Corrêa, Diogo Goulart Tijms, Betty M. Dicks, Ellen Rêgo, Cláudia Alves‐Leon, Soniza Vieira Marcondes, Jorge Gasparetto, Emerson Leandro van Duinkerken, Eelco |
author_facet | Corrêa, Diogo Goulart Tijms, Betty M. Dicks, Ellen Rêgo, Cláudia Alves‐Leon, Soniza Vieira Marcondes, Jorge Gasparetto, Emerson Leandro van Duinkerken, Eelco |
author_sort | Corrêa, Diogo Goulart |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Temporal lobe epilepsy secondary to hippocampal sclerosis is related to epileptogenic networks rather than a focal epileptogenic source. Graph‐theoretical gray and white matter networks may help to identify alterations within these epileptogenic networks. METHODS: Twenty‐seven patients with hippocampal sclerosis and 14 controls underwent magnetic resonance imaging, including 3D‐T1, fluid‐attenuated inversion recovery, and diffusion tensor imaging. Subject‐specific structural gray and white matter network properties (normalized path length, clustering, and small‐worldness) were reconstructed. Group differences and differences between those with higher and lower seizure burden (<4 vs. ≥4 average monthly seizures in the last year) in network parameters were evaluated. Additionally, correlations between network properties and disease‐related variables were calculated. RESULTS: All patients with hippocampal sclerosis as one group did not have altered gray or white matter network properties (all p > .05). Patients with lower seizure burden had significantly lower gray matter small‐worldness and normalized clustering compared to controls and those with higher seizure burden (all p < .04). A higher number of monthly seizures was significantly associated with increased gray and white matter small‐worldness, indicating a more rigid network. CONCLUSION: Overall, there were no differences in network properties in this group of patients with hippocampal sclerosis. However, patients with lower seizure burden had significantly lower gray matter network indices, indicating a more random organization. The correlation between higher monthly seizures and a more rigid network is driven by those with higher seizure burden, who presented a more rigid network compared to those with a lower seizure burden. |
format | Online Article Text |
id | pubmed-8413824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84138242021-09-07 Effects of seizure burden on structural global brain networks in patients with unilateral hippocampal sclerosis Corrêa, Diogo Goulart Tijms, Betty M. Dicks, Ellen Rêgo, Cláudia Alves‐Leon, Soniza Vieira Marcondes, Jorge Gasparetto, Emerson Leandro van Duinkerken, Eelco Brain Behav Original Research BACKGROUND AND PURPOSE: Temporal lobe epilepsy secondary to hippocampal sclerosis is related to epileptogenic networks rather than a focal epileptogenic source. Graph‐theoretical gray and white matter networks may help to identify alterations within these epileptogenic networks. METHODS: Twenty‐seven patients with hippocampal sclerosis and 14 controls underwent magnetic resonance imaging, including 3D‐T1, fluid‐attenuated inversion recovery, and diffusion tensor imaging. Subject‐specific structural gray and white matter network properties (normalized path length, clustering, and small‐worldness) were reconstructed. Group differences and differences between those with higher and lower seizure burden (<4 vs. ≥4 average monthly seizures in the last year) in network parameters were evaluated. Additionally, correlations between network properties and disease‐related variables were calculated. RESULTS: All patients with hippocampal sclerosis as one group did not have altered gray or white matter network properties (all p > .05). Patients with lower seizure burden had significantly lower gray matter small‐worldness and normalized clustering compared to controls and those with higher seizure burden (all p < .04). A higher number of monthly seizures was significantly associated with increased gray and white matter small‐worldness, indicating a more rigid network. CONCLUSION: Overall, there were no differences in network properties in this group of patients with hippocampal sclerosis. However, patients with lower seizure burden had significantly lower gray matter network indices, indicating a more random organization. The correlation between higher monthly seizures and a more rigid network is driven by those with higher seizure burden, who presented a more rigid network compared to those with a lower seizure burden. John Wiley and Sons Inc. 2021-06-09 /pmc/articles/PMC8413824/ /pubmed/34105906 http://dx.doi.org/10.1002/brb3.2237 Text en © 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Corrêa, Diogo Goulart Tijms, Betty M. Dicks, Ellen Rêgo, Cláudia Alves‐Leon, Soniza Vieira Marcondes, Jorge Gasparetto, Emerson Leandro van Duinkerken, Eelco Effects of seizure burden on structural global brain networks in patients with unilateral hippocampal sclerosis |
title | Effects of seizure burden on structural global brain networks in patients with unilateral hippocampal sclerosis |
title_full | Effects of seizure burden on structural global brain networks in patients with unilateral hippocampal sclerosis |
title_fullStr | Effects of seizure burden on structural global brain networks in patients with unilateral hippocampal sclerosis |
title_full_unstemmed | Effects of seizure burden on structural global brain networks in patients with unilateral hippocampal sclerosis |
title_short | Effects of seizure burden on structural global brain networks in patients with unilateral hippocampal sclerosis |
title_sort | effects of seizure burden on structural global brain networks in patients with unilateral hippocampal sclerosis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413824/ https://www.ncbi.nlm.nih.gov/pubmed/34105906 http://dx.doi.org/10.1002/brb3.2237 |
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