5′-tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection

Accumulating evidence shows that tRNA-derived fragments are a novel class of functional small non-coding RNA; however, their roles in aortic dissection (AD) are still unknown. In this study, we found that 5′-tiRNA-Cys-GCA was significantly downregulated in human and mouse models of aortic dissection...

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Detalles Bibliográficos
Autores principales: Zong, Tingyu, Yang, Yanyan, Lin, Xiaotong, Jiang, Shaoyan, Zhao, Hui, Liu, Meixin, Meng, Yuanyuan, Li, Yong, Zhao, Liang, Tang, Guozhang, Gong, Kun, Wang, Zhibin, Yu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413832/
https://www.ncbi.nlm.nih.gov/pubmed/34513311
http://dx.doi.org/10.1016/j.omtn.2021.07.013

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