Cargando…

CABE-RY: A PAM-flexible dual-mutation base editor for reliable modeling of multi-nucleotide variants

Multi-nucleotide variants (MNVs) represent an important type of genetic variation and have biological and clinical significance. To simulate MNVs, we designed four dual-mutation base editors combining hA3A(Y130F), TadA8e(V106W), and protospacer adjacent motif (PAM)-flexible SpRY and selected cytosin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tao, Wanyu, Liu, Qing, Huang, Shisheng, Wang, Xin, Qu, Shiyuan, Guo, Junfan, Ou, Danfeng, Li, Guanglei, Zhang, Yu, Xu, Xiangmin, Huang, Xingxu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413891/ https://www.ncbi.nlm.nih.gov/pubmed/34513298 http://dx.doi.org/10.1016/j.omtn.2021.07.016

Ejemplares similares

Engineering of near-PAMless adenine base editor with enhanced editing activity and reduced off-target
por: Cao, Xiaofang, et al.
Publicado: (2022)

Engineered prime editors with PAM flexibility
por: Kweon, Jiyeon, et al.
Publicado: (2021)

Cabe Aristóteles
por: Thiebaut, Carlos
Publicado: (1988)

SpRY greatly expands the genome editing scope in rice with highly flexible PAM recognition
por: Xu, Ziyan, et al.
Publicado: (2021)

Improving Editing Efficiency for the Sequences with NGH PAM Using xCas9-Derived Base Editors
por: Liu, Xinyi, et al.
Publicado: (2019)

Can SpRY recognize any PAM in human cells?
por: YE, Jinbin, et al.
Publicado: (2022)

Letter to the Baltimore Editor, from J. C. McCabe, of Richmond, Va.
Publicado: (1841)

Jack R. MacCabe
Publicado: (1960)

J. R. MacCabe
Publicado: (1960)

Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR‐Mediated Base Editors
por: Li, Jianan, et al.
Publicado: (2022)

Engineering an adenine base editor in human embryonic stem cells with minimal DNA and RNA off-target activities
por: Zhang, Zhenwu, et al.
Publicado: (2022)

PAM-flexible dual base editor-mediated random mutagenesis and self-activation strategies to improve CRISPRa potency
por: Lau, Cia-Hin, et al.
Publicado: (2022)

Dr. M'Cabe on the Cheltenham Waters, and the Diseases in Which They Are Recommended
Publicado: (1821)

A Cas-embedding strategy for minimizing off-target effects of DNA base editors
por: Liu, Yajing, et al.
Publicado: (2020)

Efficient Gene Silencing by Adenine Base Editor-Mediated Start Codon Mutation
por: Wang, Xinjie, et al.
Publicado: (2020)

Nucleic acid ligands act as a PAM and agonist depending on the intrinsic ligand binding state of P2RY2
por: Takahashi, Masaki, et al.
Publicado: (2021)

McCabe score as a strong determinant of septic shock-related mortality
por: Delodder, F, et al.
Publicado: (2011)

Jack Redpath MacCabe, M.Sc., B.Sc.: text in English
por: CERN Press Office. Geneva
Publicado: (1960)

A novel base editor SpRY-ABE8e(F148A) mediates efficient A-to-G base editing with a reduced off-target effect
por: Li, Guo, et al.
Publicado: (2022)

A, arte, bajo, cabe, con, contra, de, desde -- : nociones para escribir un proyecto de arte /
por: Álvarez Romero, Ekaterina
Publicado: (2017)

From left : J. MacCabe, Hammarskjold, C. J. Bakker and F. Perrin
por: CERN PhotoLab
Publicado: (1958)

Jack Redpath MacCabe, M.Sc., B.Sc.: texte en français
por: CERN Press Office. Geneva
Publicado: (1960)

CABeRNET: a Cytoscape app for augmented Boolean models of gene regulatory NETworks
por: Paroni, Andrea, et al.
Publicado: (2016)

PAM-Flexible Genome Editing with an Engineered Chimeric Cas9
por: Koseki, Sabrina, et al.
Publicado: (2023)

PAM-flexible genome editing with an engineered chimeric Cas9
por: Zhao, Lin, et al.
Publicado: (2023)

CABE: A Cloud-Based Acoustic Beamforming Emulator for FPGA-Based Sound Source Localization
por: Segers, Laurent, et al.
Publicado: (2019)

Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity
por: Li, Jianan, et al.
Publicado: (2021)

Measuring patient activation in Chinese patients with hypertension and/or diabetes: reliability and validity of the PAM13
por: Zeng, Huijuan, et al.
Publicado: (2019)

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
por: Huang, Tony P., et al.
Publicado: (2019)

A massively parallel approach for assessing CRISPR off-targets in vitro
por: Huang, Shisheng, et al.
Publicado: (2023)

Enhancement of prime editing via xrRNA motif-joined pegRNA
por: Zhang, Guiquan, et al.
Publicado: (2022)

Exploiting the CRISPR/Cas9 PAM Constraint for Single-Nucleotide Resolution Interventions
por: Li, Yi, et al.
Publicado: (2016)

Testing the validation and reliability of the Caregiver-Patient Activation Measure (CG-PAM)
por: Carleton-Eagleton, Katherine, et al.
Publicado: (2022)

High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs
por: Huang, Tony P., et al.
Publicado: (2022)

A modified McCabe score for stratification of patients after intensive care unit discharge: the Sabadell score
por: Fernandez, Rafael, et al.
Publicado: (2006)

Penta- and hexa-coordinated beryllium and phosphorus in high-pressure modifications of CaBe(2)P(2)O(8)
por: Pakhomova, Anna, et al.
Publicado: (2019)

Comparison of gene disruption induced by cytosine base editing‐mediated iSTOP with CRISPR/Cas9‐mediated frameshift
por: Dang, Lu, et al.
Publicado: (2020)

Harnessing A3G for efficient and selective C-to-T conversion at C-rich sequences
por: Yu, Wenxia, et al.
Publicado: (2021)

Development of a versatile nuclease prime editor with upgraded precision
por: Li, Xiangyang, et al.
Publicado: (2023)

Adaptation of a patient activation measure (PAM) into Turkish: reliability and validity test
por: Kosar, Cansu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_k1cjfqbt34l7mcvgq88h6kufmn