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Biomarkers of inflammation and fibrosis in young adults with history of Kawasaki disease()

BACKGROUND: Myocardial histology from autopsies of young adults with giant coronary artery aneurysms following Kawasaki disease (KD) shows bridging fibrosis beyond the territories supplied by the aneurysmal arteries. The etiology of this fibrosis is unknown, but persistent, low-level myocardial infl...

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Autores principales: Hoshino, Shinsuke, Jain, Sonia, Shimizu, Chisato, Roberts, Samantha, He, Feng, Daniels, Lori B., Kahn, Andrew M., Tremoulet, Adriana H., Gordon, John B., Burns, Jane C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413893/
https://www.ncbi.nlm.nih.gov/pubmed/34504945
http://dx.doi.org/10.1016/j.ijcha.2021.100863
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author Hoshino, Shinsuke
Jain, Sonia
Shimizu, Chisato
Roberts, Samantha
He, Feng
Daniels, Lori B.
Kahn, Andrew M.
Tremoulet, Adriana H.
Gordon, John B.
Burns, Jane C.
author_facet Hoshino, Shinsuke
Jain, Sonia
Shimizu, Chisato
Roberts, Samantha
He, Feng
Daniels, Lori B.
Kahn, Andrew M.
Tremoulet, Adriana H.
Gordon, John B.
Burns, Jane C.
author_sort Hoshino, Shinsuke
collection PubMed
description BACKGROUND: Myocardial histology from autopsies of young adults with giant coronary artery aneurysms following Kawasaki disease (KD) shows bridging fibrosis beyond the territories supplied by the aneurysmal arteries. The etiology of this fibrosis is unknown, but persistent, low-level myocardial inflammation and microcirculatory ischemia are both possible contributing factors. To investigate the possibility of subclinical myocardial inflammation or fibrosis, we measured validated biomarkers in young adults with a remote history of KD. METHODS: We measured plasma calprotectin, galectin-3 (Gal-3), growth differentiation factor-15 (GDF-15), soluble ST2 (sST2), and serum procollagen type 1C-terminal propeptide (P1CP) in 91 otherwise healthy young adults with a remote history of KD and in 88 age-similar, healthy controls. KD subjects were stratified by coronary artery aneurysm (CAA) status and history of remote myocardial infarction (MI). RESULTS: After correction for multiple testing, calprotectin, Gal-3, and GDF-15 levels were significantly higher in subjects with persistent CAA (n = 26) compared with KD subjects with remodeled CAA (n = 20, p = 0.005, 0.001, 0.0036, respectively). In a multivariable regression model with CA status as the main predictor and adjusting for sex, MI history, and interval from KD onset, CA status was a significant predictor (Persistent CAA vs KD Normal CA) of calprotectin, Gal-3, GDF-15 and sST2 levels (p = 0.004, <0.001, 0.007, and 0.049, respectively). CONCLUSIONS: These results suggest that ongoing inflammation and fibrosis may be occurring in individuals with persistent CAA. Longitudinal follow-up is needed to clarify the clinical significance of these elevated biomarker levels in this patient population that requires life-long monitoring.
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spelling pubmed-84138932021-09-08 Biomarkers of inflammation and fibrosis in young adults with history of Kawasaki disease() Hoshino, Shinsuke Jain, Sonia Shimizu, Chisato Roberts, Samantha He, Feng Daniels, Lori B. Kahn, Andrew M. Tremoulet, Adriana H. Gordon, John B. Burns, Jane C. Int J Cardiol Heart Vasc Original Paper BACKGROUND: Myocardial histology from autopsies of young adults with giant coronary artery aneurysms following Kawasaki disease (KD) shows bridging fibrosis beyond the territories supplied by the aneurysmal arteries. The etiology of this fibrosis is unknown, but persistent, low-level myocardial inflammation and microcirculatory ischemia are both possible contributing factors. To investigate the possibility of subclinical myocardial inflammation or fibrosis, we measured validated biomarkers in young adults with a remote history of KD. METHODS: We measured plasma calprotectin, galectin-3 (Gal-3), growth differentiation factor-15 (GDF-15), soluble ST2 (sST2), and serum procollagen type 1C-terminal propeptide (P1CP) in 91 otherwise healthy young adults with a remote history of KD and in 88 age-similar, healthy controls. KD subjects were stratified by coronary artery aneurysm (CAA) status and history of remote myocardial infarction (MI). RESULTS: After correction for multiple testing, calprotectin, Gal-3, and GDF-15 levels were significantly higher in subjects with persistent CAA (n = 26) compared with KD subjects with remodeled CAA (n = 20, p = 0.005, 0.001, 0.0036, respectively). In a multivariable regression model with CA status as the main predictor and adjusting for sex, MI history, and interval from KD onset, CA status was a significant predictor (Persistent CAA vs KD Normal CA) of calprotectin, Gal-3, GDF-15 and sST2 levels (p = 0.004, <0.001, 0.007, and 0.049, respectively). CONCLUSIONS: These results suggest that ongoing inflammation and fibrosis may be occurring in individuals with persistent CAA. Longitudinal follow-up is needed to clarify the clinical significance of these elevated biomarker levels in this patient population that requires life-long monitoring. Elsevier 2021-09-01 /pmc/articles/PMC8413893/ /pubmed/34504945 http://dx.doi.org/10.1016/j.ijcha.2021.100863 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Paper
Hoshino, Shinsuke
Jain, Sonia
Shimizu, Chisato
Roberts, Samantha
He, Feng
Daniels, Lori B.
Kahn, Andrew M.
Tremoulet, Adriana H.
Gordon, John B.
Burns, Jane C.
Biomarkers of inflammation and fibrosis in young adults with history of Kawasaki disease()
title Biomarkers of inflammation and fibrosis in young adults with history of Kawasaki disease()
title_full Biomarkers of inflammation and fibrosis in young adults with history of Kawasaki disease()
title_fullStr Biomarkers of inflammation and fibrosis in young adults with history of Kawasaki disease()
title_full_unstemmed Biomarkers of inflammation and fibrosis in young adults with history of Kawasaki disease()
title_short Biomarkers of inflammation and fibrosis in young adults with history of Kawasaki disease()
title_sort biomarkers of inflammation and fibrosis in young adults with history of kawasaki disease()
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413893/
https://www.ncbi.nlm.nih.gov/pubmed/34504945
http://dx.doi.org/10.1016/j.ijcha.2021.100863
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