Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling

Genetic studies have identified BIN1 as the second most important risk locus associated with late-onset Alzheimer's disease (LOAD). However, it is unclear how mutation of this locus mechanistically promotes Alzheimer’s disease (AD) pathology. Here we show the consequences of two coding variants...

Descripción completa

Detalles Bibliográficos
Autores principales: Perdigão, Catarina, Barata, Mariana A., Burrinha, Tatiana, Guimas Almeida, Cláudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413894/
https://www.ncbi.nlm.nih.gov/pubmed/34375641
http://dx.doi.org/10.1016/j.jbc.2021.101056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413894/
https://www.ncbi.nlm.nih.gov/pubmed/34375641
http://dx.doi.org/10.1016/j.jbc.2021.101056

Ejemplares similares