Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling

Genetic studies have identified BIN1 as the second most important risk locus associated with late-onset Alzheimer's disease (LOAD). However, it is unclear how mutation of this locus mechanistically promotes Alzheimer’s disease (AD) pathology. Here we show the consequences of two coding variants...

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Detalles Bibliográficos
Autores principales: Perdigão, Catarina, Barata, Mariana A., Burrinha, Tatiana, Guimas Almeida, Cláudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413894/
https://www.ncbi.nlm.nih.gov/pubmed/34375641
http://dx.doi.org/10.1016/j.jbc.2021.101056

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