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Irisin ameliorates doxorubicin-induced cardiac perivascular fibrosis through inhibiting endothelial-to-mesenchymal transition by regulating ROS accumulation and autophagy disorder in endothelial cells

The dose-dependent toxicity to cardiomyocytes has been well recognized as a central characteristic of doxorubicin (DOX)-induced cardiotoxicity (DIC), however, the pathogenesis of DIC in the cardiac microenvironment remains elusive. Irisin is a new hormone-like myokine released into the circulation i...

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Detalles Bibliográficos
Autores principales:	Pan, Jian-an, Zhang, Hui, Lin, Hao, Gao, Lin, Zhang, Hui-li, Zhang, Jun-feng, Wang, Chang-qian, Gu, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413906/ https://www.ncbi.nlm.nih.gov/pubmed/34479089 http://dx.doi.org/10.1016/j.redox.2021.102120

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