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High-dose IL-2/CD25 fusion protein amplifies vaccine-induced CD4(+) and CD8(+) neoantigen-specific T cells to promote antitumor immunity

BACKGROUND: Immunization with tumor neoantigens is a promising vaccine approach to promote antitumor immunity due to their high immunogenicity, lack of expression in normal tissue, and preferential induction of tumor neoantigen-specific T cells, which are central mediators of the anti-cancer respons...

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Detalles Bibliográficos
Autores principales:	Hernandez, Rosmely, LaPorte, Kathryn M, Hsiung, Sunnie, Santos Savio, Alicia, Malek, Thomas R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413969/ https://www.ncbi.nlm.nih.gov/pubmed/34475132 http://dx.doi.org/10.1136/jitc-2021-002865

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