Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer

Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids, RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential intercellular communication regulators in multiple physiological and pathological processes. Previous studies revealed that me...

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Autores principales: Weng, Zhijie, Zhang, Bowen, Wu, Chenzhou, Yu, Fanyuan, Han, Bo, Li, Bo, Li, Longjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414028/
https://www.ncbi.nlm.nih.gov/pubmed/34479611
http://dx.doi.org/10.1186/s13045-021-01141-y
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author Weng, Zhijie
Zhang, Bowen
Wu, Chenzhou
Yu, Fanyuan
Han, Bo
Li, Bo
Li, Longjiang
author_facet Weng, Zhijie
Zhang, Bowen
Wu, Chenzhou
Yu, Fanyuan
Han, Bo
Li, Bo
Li, Longjiang
author_sort Weng, Zhijie
collection PubMed
description Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids, RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential intercellular communication regulators in multiple physiological and pathological processes. Previous studies revealed that mesenchymal stem cells (MSCs) could either support or suppress tumor progression in different cancers by paracrine signaling via MSC-derived EVs. Evidence suggested that MSC-derived EVs could mimic their parental cells, possessing pro-tumor and anti-tumor effects, and inherent tumor tropism. Therefore, MSC-derived EVs can be a cell-free cancer treatment alternative. This review discusses different insights regarding MSC-derived EVs' roles in cancer treatment and summarizes bioengineered MSC-derived EVs’ applications as safe and versatile anti-tumor agent delivery platforms. Meanwhile, current hurdles of moving MSC-derived EVs from bench to bedside are also discussed.
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spelling pubmed-84140282021-09-03 Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer Weng, Zhijie Zhang, Bowen Wu, Chenzhou Yu, Fanyuan Han, Bo Li, Bo Li, Longjiang J Hematol Oncol Review Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids, RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential intercellular communication regulators in multiple physiological and pathological processes. Previous studies revealed that mesenchymal stem cells (MSCs) could either support or suppress tumor progression in different cancers by paracrine signaling via MSC-derived EVs. Evidence suggested that MSC-derived EVs could mimic their parental cells, possessing pro-tumor and anti-tumor effects, and inherent tumor tropism. Therefore, MSC-derived EVs can be a cell-free cancer treatment alternative. This review discusses different insights regarding MSC-derived EVs' roles in cancer treatment and summarizes bioengineered MSC-derived EVs’ applications as safe and versatile anti-tumor agent delivery platforms. Meanwhile, current hurdles of moving MSC-derived EVs from bench to bedside are also discussed. BioMed Central 2021-09-03 /pmc/articles/PMC8414028/ /pubmed/34479611 http://dx.doi.org/10.1186/s13045-021-01141-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Weng, Zhijie
Zhang, Bowen
Wu, Chenzhou
Yu, Fanyuan
Han, Bo
Li, Bo
Li, Longjiang
Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer
title Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer
title_full Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer
title_fullStr Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer
title_full_unstemmed Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer
title_short Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer
title_sort therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414028/
https://www.ncbi.nlm.nih.gov/pubmed/34479611
http://dx.doi.org/10.1186/s13045-021-01141-y
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