The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal Immunobiology

The ocular tissue microenvironment is immune privileged and uses several mechanisms of immunosuppression to prevent the induction of inflammation. Besides being a blood-barrier and source of photoreceptor nutrients, the retinal pigment epithelial cells (RPE) regulate the activity of immune cells wit...

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Detalles Bibliográficos
Autores principales: Taylor, Andrew W., Hsu, Samuel, Ng, Tat Fong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414138/
https://www.ncbi.nlm.nih.gov/pubmed/34484232
http://dx.doi.org/10.3389/fimmu.2021.724601
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author Taylor, Andrew W.
Hsu, Samuel
Ng, Tat Fong
author_facet Taylor, Andrew W.
Hsu, Samuel
Ng, Tat Fong
author_sort Taylor, Andrew W.
collection PubMed
description The ocular tissue microenvironment is immune privileged and uses several mechanisms of immunosuppression to prevent the induction of inflammation. Besides being a blood-barrier and source of photoreceptor nutrients, the retinal pigment epithelial cells (RPE) regulate the activity of immune cells within the retina. These mechanisms involve the expression of immunomodulating molecules that make macrophages and microglial cells suppress inflammation and promote immune tolerance. The RPE have an important role in ocular immune privilege to regulate the behavior of immune cells within the retina. Reviewed is the current understanding of how RPE mediate this regulation and the changes seen under pathological conditions.
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spelling pubmed-84141382021-09-04 The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal Immunobiology Taylor, Andrew W. Hsu, Samuel Ng, Tat Fong Front Immunol Immunology The ocular tissue microenvironment is immune privileged and uses several mechanisms of immunosuppression to prevent the induction of inflammation. Besides being a blood-barrier and source of photoreceptor nutrients, the retinal pigment epithelial cells (RPE) regulate the activity of immune cells within the retina. These mechanisms involve the expression of immunomodulating molecules that make macrophages and microglial cells suppress inflammation and promote immune tolerance. The RPE have an important role in ocular immune privilege to regulate the behavior of immune cells within the retina. Reviewed is the current understanding of how RPE mediate this regulation and the changes seen under pathological conditions. Frontiers Media S.A. 2021-08-13 /pmc/articles/PMC8414138/ /pubmed/34484232 http://dx.doi.org/10.3389/fimmu.2021.724601 Text en Copyright © 2021 Taylor, Hsu and Ng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Taylor, Andrew W.
Hsu, Samuel
Ng, Tat Fong
The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal Immunobiology
title The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal Immunobiology
title_full The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal Immunobiology
title_fullStr The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal Immunobiology
title_full_unstemmed The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal Immunobiology
title_short The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal Immunobiology
title_sort role of retinal pigment epithelial cells in regulation of macrophages/microglial cells in retinal immunobiology
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414138/
https://www.ncbi.nlm.nih.gov/pubmed/34484232
http://dx.doi.org/10.3389/fimmu.2021.724601
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