(E)-7-Ethylidene-lithocholic Acid (7-ELCA) Is a Potent Dual Farnesoid X Receptor (FXR) Antagonist and GPBAR1 Agonist Inhibiting FXR-Induced Gene Expression in Hepatocytes and Stimulating Glucagon-like Peptide-1 Secretion From Enteroendocrine Cells

Bile acids (BAs) are key signaling steroidal molecules that regulate glucose, lipid, and energy homeostasis via interactions with the farnesoid X receptor (FXR) and G-protein bile acid receptor 1 (GPBAR1). Extensive medicinal chemistry modifications of the BA scaffold led to the discovery of potent...

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Detalles Bibliográficos
Autores principales: Stefela, Alzbeta, Kaspar, Miroslav, Drastik, Martin, Kronenberger, Thales, Micuda, Stanislav, Dracinsky, Martin, Klepetarova, Blanka, Kudova, Eva, Pavek, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414367/
https://www.ncbi.nlm.nih.gov/pubmed/34483922
http://dx.doi.org/10.3389/fphar.2021.713149

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