Cargando…

They Might Cut It—Lysosomes and Autophagy in Mitotic Progression

The division of one cell into two looks so easy, as if it happens without any control at all. Mitosis, the hallmark of mammalian life is, however, tightly regulated from the early onset to the very last phase. Despite the tight control, errors in mitotic division occur frequently and they may result...

Descripción completa

Detalles Bibliográficos
Autores principales: Hämälistö, Saara, Stahl-Meyer, Jonathan, Jäättelä, Marja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414588/
https://www.ncbi.nlm.nih.gov/pubmed/34485308
http://dx.doi.org/10.3389/fcell.2021.727538
_version_ 1783747808525811712
author Hämälistö, Saara
Stahl-Meyer, Jonathan
Jäättelä, Marja
author_facet Hämälistö, Saara
Stahl-Meyer, Jonathan
Jäättelä, Marja
author_sort Hämälistö, Saara
collection PubMed
description The division of one cell into two looks so easy, as if it happens without any control at all. Mitosis, the hallmark of mammalian life is, however, tightly regulated from the early onset to the very last phase. Despite the tight control, errors in mitotic division occur frequently and they may result in various chromosomal instabilities and malignancies. The flow of events during mitotic progression where the chromosomes condensate and rearrange with the help of the cytoskeletal network has been described in great detail. Plasma membrane dynamics and endocytic vesicle movement upon deadhesion and reattachment of dividing cells are also demonstrated to be functionally important for the mitotic integrity. Other cytoplasmic organelles, such as autophagosomes and lysosomes, have until recently been considered merely as passive bystanders in this process. Accordingly, at the onset of nuclear envelope breakdown in prometaphase, the number of autophagic structures and lysosomes is reduced and the bulk autophagic machinery is suppressed for the duration of mitosis. This is believed to ensure that the exposed nuclear components are not unintentionally delivered to autophagic degradation. With the evolving technologies that allow the detection of subtle alterations in cytoplasmic organelles, our understanding of the small-scale regulation of intracellular organelles has deepened rapidly and we discuss here recent discoveries revealing unexpected roles for autophagy and lysosomes in the preservation of genomic integrity during mitosis.
format Online
Article
Text
id pubmed-8414588
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-84145882021-09-04 They Might Cut It—Lysosomes and Autophagy in Mitotic Progression Hämälistö, Saara Stahl-Meyer, Jonathan Jäättelä, Marja Front Cell Dev Biol Cell and Developmental Biology The division of one cell into two looks so easy, as if it happens without any control at all. Mitosis, the hallmark of mammalian life is, however, tightly regulated from the early onset to the very last phase. Despite the tight control, errors in mitotic division occur frequently and they may result in various chromosomal instabilities and malignancies. The flow of events during mitotic progression where the chromosomes condensate and rearrange with the help of the cytoskeletal network has been described in great detail. Plasma membrane dynamics and endocytic vesicle movement upon deadhesion and reattachment of dividing cells are also demonstrated to be functionally important for the mitotic integrity. Other cytoplasmic organelles, such as autophagosomes and lysosomes, have until recently been considered merely as passive bystanders in this process. Accordingly, at the onset of nuclear envelope breakdown in prometaphase, the number of autophagic structures and lysosomes is reduced and the bulk autophagic machinery is suppressed for the duration of mitosis. This is believed to ensure that the exposed nuclear components are not unintentionally delivered to autophagic degradation. With the evolving technologies that allow the detection of subtle alterations in cytoplasmic organelles, our understanding of the small-scale regulation of intracellular organelles has deepened rapidly and we discuss here recent discoveries revealing unexpected roles for autophagy and lysosomes in the preservation of genomic integrity during mitosis. Frontiers Media S.A. 2021-08-13 /pmc/articles/PMC8414588/ /pubmed/34485308 http://dx.doi.org/10.3389/fcell.2021.727538 Text en Copyright © 2021 Hämälistö, Stahl-Meyer and Jäättelä. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Hämälistö, Saara
Stahl-Meyer, Jonathan
Jäättelä, Marja
They Might Cut It—Lysosomes and Autophagy in Mitotic Progression
title They Might Cut It—Lysosomes and Autophagy in Mitotic Progression
title_full They Might Cut It—Lysosomes and Autophagy in Mitotic Progression
title_fullStr They Might Cut It—Lysosomes and Autophagy in Mitotic Progression
title_full_unstemmed They Might Cut It—Lysosomes and Autophagy in Mitotic Progression
title_short They Might Cut It—Lysosomes and Autophagy in Mitotic Progression
title_sort they might cut it—lysosomes and autophagy in mitotic progression
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414588/
https://www.ncbi.nlm.nih.gov/pubmed/34485308
http://dx.doi.org/10.3389/fcell.2021.727538
work_keys_str_mv AT hamalistosaara theymightcutitlysosomesandautophagyinmitoticprogression
AT stahlmeyerjonathan theymightcutitlysosomesandautophagyinmitoticprogression
AT jaattelamarja theymightcutitlysosomesandautophagyinmitoticprogression