Cargando…

Identification of EP300 as a Key Gene Involved in Antipsychotic-Induced Metabolic Dysregulation Based on Integrative Bioinformatics Analysis of Multi-Tissue Gene Expression Data

Antipsychotics (APs) are associated with weight gain and other metabolic abnormalities such as hyperglycemia, dyslipidemia and metabolic syndrome. This translational study aimed to uncover the underlying molecular mechanisms and identify the key genes involved in AP-induced metabolic effects. An int...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martínez-Pinteño, Albert, Gassó, Patricia, Prohens, Llucia, Segura, Alex G., Parellada, Mara, Saiz-Ruiz, Jerónimo, Cuesta, Manuel J., Bernardo, Miguel, Lafuente, Amalia, Mas, Sergi, Rodríguez, Natalia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414590/ https://www.ncbi.nlm.nih.gov/pubmed/34483940 http://dx.doi.org/10.3389/fphar.2021.729474

Ejemplares similares

Improving pharmacogenetic prediction of extrapyramidal symptoms induced by antipsychotics
por: Boloc, Daniel, et al.
Publicado: (2018)

Author Correction: Improving pharmacogenetic prediction of extrapyramidal symptoms induced by antipsychotics
por: Boloc, Daniel, et al.
Publicado: (2019)

Gene expression study in monocytes: evidence of inflammatory dysregulation in early-onset obsessive-compulsive disorder
por: Rodríguez, Natalia, et al.
Publicado: (2022)

Integrative DNA Methylation and Gene Expression Analysis of Cognitive Behavioral Therapy Response in Children and Adolescents with Obsessive-Compulsive Disorder; a Pilot Study
por: Rodriguez, Natalia, et al.
Publicado: (2021)

DNA Methylation of Fluoxetine Response in Child and Adolescence: Preliminary Results
por: Martinez-Pinteño, Albert, et al.
Publicado: (2021)

Neurotoxic/Neuroprotective Effects of Clozapine and the Positive Allosteric Modulator of mGluR2 JNJ-46356479 in Human Neuroblastoma Cell Cultures
por: Gassó, Patricia, et al.
Publicado: (2023)

Systematic Review of the Therapeutic Role of Apoptotic Inhibitors in Neurodegeneration and Their Potential Use in Schizophrenia
por: Morén, Constanza, et al.
Publicado: (2022)

Apoptotic markers in cultured fibroblasts correlate with brain metabolites and regional brain volume in antipsychotic-naive first-episode schizophrenia and healthy controls
por: Batalla, A, et al.
Publicado: (2015)

The Effect of Clozapine and Novel Glutamate Modulator JNJ-46356479 on Nitrosative Stress in a Postnatal Murine Ketamine Model of Schizophrenia
por: Treder, Nina, et al.
Publicado: (2023)

Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients
por: Rodríguez, Natalia, et al.
Publicado: (2022)

Integrating Genetic, Neuropsychological and Neuroimaging Data to Model Early-Onset Obsessive Compulsive Disorder Severity
por: Mas, Sergi, et al.
Publicado: (2016)

Correction: Integrating Genetic, Neuropsychological and Neuroimaging Data to Model Early-Onset Obsessive Compulsive Disorder Severity
por: Mas, Sergi, et al.
Publicado: (2017)

“Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300”
por: Borzì, Rosa Maria, et al.
Publicado: (2019)

Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300
por: Sacitharan, Pradeep K., et al.
Publicado: (2018)

A longitudinal study of gene expression in first-episode schizophrenia; exploring relapse mechanisms by co-expression analysis in peripheral blood
por: Gassó, P., et al.
Publicado: (2021)

A Pharmacovigilance Study in First Episode of Psychosis: Psychopharmacological Interventions and Safety Profiles in the PEPs Project
por: Bioque, Miquel, et al.
Publicado: (2015)

Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia
por: Parellada, Eduard, et al.
Publicado: (2021)

Inflammatory dysregulation of monocytes in pediatric patients with obsessive-compulsive disorder
por: Rodríguez, Natalia, et al.
Publicado: (2017)

Identification of dysregulated genes in rheumatoid arthritis based on bioinformatics analysis
por: Hao, Ruihu, et al.
Publicado: (2017)

Experimental analysis of bladder cancer-associated mutations in EP300 identifies EP300-R1627W as a driver mutation
por: Luo, Mayao, et al.
Publicado: (2023)

Epigenetic clocks in relapse after a first episode of schizophrenia
por: Segura, Àlex-González, et al.
Publicado: (2022)

Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300: response to correspondence by Borzì et al.
por: Sacitharan, Pradeep K., et al.
Publicado: (2019)

Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode
por: Segura, Alex G., et al.
Publicado: (2023)

Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene
por: Palma-Gudiel, Helena, et al.
Publicado: (2019)

Ep300 sequestration to functionally distinct glucocorticoid receptor binding loci underlie rapid gene activation and repression
por: Portuguez, Avital Sarusi, et al.
Publicado: (2022)

Pro-/Antiinflammatory Dysregulation in Early Psychosis: Results from a 1-Year Follow-Up Study
por: García-Bueno, Borja, et al.
Publicado: (2015)

EP300 Protects from Light-Induced Retinopathy in Zebrafish
por: Kawase, Reiko, et al.
Publicado: (2016)

Aspirin induces autophagy via inhibition of the acetyltransferase EP300
por: Castoldi, Francesca, et al.
Publicado: (2018)

Directional divergence of Ep300 duplicates in teleosts and its implications
por: Wang, Xianzong, et al.
Publicado: (2020)

The protective role of EP300 in monocrotaline-induced pulmonary hypertension
por: Yang, Lei, et al.
Publicado: (2023)

EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs
por: Rubio, Karla, et al.
Publicado: (2023)

Integrated bioinformatics identifies the dysregulation induced by aberrant gene methylation in colorectal carcinoma
por: Ye, Zhenyu, et al.
Publicado: (2020)

The gene expression patterns of BMPR2, EP300, TGFβ2, and TNFAIP3 in B-Lymphoma cells
por: He, Dong-Mei, et al.
Publicado: (2014)

Long-Acting Injectable Antipsychotics in First-Episode Schizophrenia
por: Parellada, Eduard, et al.
Publicado: (2012)

EP300 as an oncogene correlates with poor prognosis in esophageal squamous carcinoma
por: Bi, Yanghui, et al.
Publicado: (2019)

EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma
por: Durbin, Adam D., et al.
Publicado: (2022)

The Role of CREBBP/EP300 and Its Therapeutic Implications in Hematological Malignancies
por: Zhu, Yu, et al.
Publicado: (2023)

Comparative analysis of drug-like EP300/CREBBP acetyltransferase inhibitors
por: Crawford, McKenna C., et al.
Publicado: (2023)

Pre-B acute lymphoblastic leukaemia recurrent fusion, EP300-ZNF384, is associated with a distinct gene expression
por: McClure, Barbara J., et al.
Publicado: (2018)

Detection of EP300-ZNF384 fusion in patients with acute lymphoblastic leukemia using RNA fusion gene panel sequencing
por: Jing, Yu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dpnol1b9t4jmjc3d6sljmgngrp