A Multiple Step Active Stiffness Integration Scheme to Couple a Stochastic Cross-Bridge Model and Continuum Mechanics for Uses in Both Basic Research and Clinical Applications of Heart Simulation

In a multiscale simulation of a beating heart, the very large difference in the time scales between rapid stochastic conformational changes of contractile proteins and deterministic macroscopic outcomes, such as the ventricular pressure and volume, have hampered the implementation of an efficient co...

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Detalles Bibliográficos
Autores principales: Yoneda, Kazunori, Okada, Jun-ichi, Watanabe, Masahiro, Sugiura, Seiryo, Hisada, Toshiaki, Washio, Takumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414591/
https://www.ncbi.nlm.nih.gov/pubmed/34483965
http://dx.doi.org/10.3389/fphys.2021.712816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414591/
https://www.ncbi.nlm.nih.gov/pubmed/34483965
http://dx.doi.org/10.3389/fphys.2021.712816

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