Cargando…

Prednisone Reprograms the Transcriptional Immune Cell Landscape in CNS Autoimmune Disease

Glucocorticoids (GCs) are widely used immunosuppressive drugs for autoimmune diseases, although considerable gaps exist between current knowledge of the mechanisms of GCs and their conclusive immune-regulatory effects. Here we generated a single-cell transcriptional immune cell atlas based on predni...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, He, Gao, Yuehan, Xie, Lihui, Wang, Rong, Duan, Runping, Li, Zhaohuai, Chen, Binyao, Zhu, Lei, Wang, Xianggui, Su, Wenru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414592/ https://www.ncbi.nlm.nih.gov/pubmed/34484247 http://dx.doi.org/10.3389/fimmu.2021.739605

Ejemplares similares

Therapeutic Effect of IL-38 on Experimental Autoimmune Uveitis: Reprogrammed Immune Cell Landscape and Reduced Th17 Cell Pathogenicity
por: Li, He, et al.
Publicado: (2021)

Effects of poor sleep on the immune cell landscape as assessed by single-cell analysis
por: Liu, Xiuxing, et al.
Publicado: (2021)

Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis
por: Huang, Zhaohao, et al.
Publicado: (2021)

Single-cell RNA sequencing depicts the local cell landscape in thyroid-associated ophthalmopathy
por: Li, Zhaohuai, et al.
Publicado: (2022)

Single-cell analysis of immune cells on gingiva-derived mesenchymal stem cells in experimental autoimmune uveitis
por: Gao, Yuehan, et al.
Publicado: (2023)

TNF-α in Uveitis: From Bench to Clinic
por: Jiang, Qi, et al.
Publicado: (2021)

Corrigendum: TNF-α in Uveitis: From Bench to Clinic
por: Jiang, Qi, et al.
Publicado: (2022)

The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID‐19
por: Tang, Hao, et al.
Publicado: (2020)

Identification of Hif1α as a Potential Participant in Autoimmune Uveitis Pathogenesis Using Single-Cell Transcriptome Analysis
por: Zhu, Lei, et al.
Publicado: (2023)

Sleep loss potentiates Th17‐cell pathogenicity and promotes autoimmune uveitis
por: Liu, Xiuxing, et al.
Publicado: (2023)

Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice
por: Li, He, et al.
Publicado: (2021)

Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitis
por: Li, He, et al.
Publicado: (2022)

Systemic glucocorticoid-free therapy with adalimumab plus immunosuppressants versus conventional therapy in treatment-naïve Vogt-Koyanagi-Harada disease patients
por: Yang, Shizhao, et al.
Publicado: (2022)

Therapeutic Effects of Upadacitinib on Experimental Autoimmune Uveitis: Insights From Single-Cell Analysis
por: Huang, Zhaohao, et al.
Publicado: (2023)

A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis
por: Zhu, Lei, et al.
Publicado: (2021)

Unraveling the Heterogeneity and Ontogeny of Dendritic Cells Using Single-Cell RNA Sequencing
por: Chen, Binyao, et al.
Publicado: (2021)

Autophagy and Autophagy-Related Proteins in CNS Autoimmunity
por: Keller, Christian W., et al.
Publicado: (2017)

The roles of fungus in CNS autoimmune and neurodegeneration disorders
por: Wu, Chuyu, et al.
Publicado: (2023)

The Role of Latently Infected B Cells in CNS Autoimmunity
por: Márquez, Ana Citlali, et al.
Publicado: (2015)

Insights gained from single-cell analysis of immune cells in tofacitinib treatment of Vogt-Koyanagi-Harada disease
por: Liu, Xiuxing, et al.
Publicado: (2022)

Matrine Inhibits CNS Autoimmunity Through an IFN-β-Dependent Mechanism
por: Chu, Yao-Juan, et al.
Publicado: (2020)

Clinical features of myasthenia gravis with neurological and systemic autoimmune diseases
por: Zhu, Ying, et al.
Publicado: (2023)

IL-3 Is a Marker of Encephalitogenic T Cells, but Not Essential for CNS Autoimmunity
por: Lee, Priscilla W., et al.
Publicado: (2018)

Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation
por: Linnerbauer, Mathias, et al.
Publicado: (2022)

Editorial: The role of immune cells in the progression of autoimmune diseases affecting the CNS
por: Kowal, Czeslawa, et al.
Publicado: (2022)

The Changing Landscape of Autoimmune Hemolytic Anemia
por: Barcellini, Wilma, et al.
Publicado: (2020)

Hypothesis of a potential BrainBiota and its relation to CNS autoimmune inflammation
por: Elkjaer, Maria L., et al.
Publicado: (2022)

Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells
por: Sabbagh, Mark F, et al.
Publicado: (2018)

CNS and CNS diseases in relation to their immune system
por: Xu, Jianhao, et al.
Publicado: (2022)

p38 MAP Kinase Signaling in Microglia Plays a Sex-Specific Protective Role in CNS Autoimmunity and Regulates Microglial Transcriptional States
por: McGill, Mahalia M., et al.
Publicado: (2021)

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
por: Evonuk, Kirsten S., et al.
Publicado: (2016)

Mast Cells and Innate Lymphoid Cells: Underappreciated Players in CNS Autoimmune Demyelinating Disease
por: Brown, Melissa A., et al.
Publicado: (2018)

Chemokine-Driven Migration of Pro-Inflammatory CD4(+) T Cells in CNS Autoimmune Disease
por: Heng, Aaron H. S., et al.
Publicado: (2022)

Post-Infectious Autoimmunity in the Central (CNS) and Peripheral (PNS) Nervous Systems: An African Perspective
por: Ndondo, Alvin Pumelele, et al.
Publicado: (2022)

Comparative effects of human-equivalent low, moderate, and high dose oral prednisone intake on autoimmunity and glucocorticoid-related toxicity in a murine model of environmental-triggered lupus
por: Heine, Lauren K., et al.
Publicado: (2022)

The iNOS Activity During an Immune Response Controls the CNS Pathology in Experimental Autoimmune Encephalomyelitis
por: Sonar, Sandip Ashok, et al.
Publicado: (2019)

γδ T Cells and NK Cells – Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity
por: Edwards, Sarah C., et al.
Publicado: (2015)

T-bet Expression by Foxp3(+) T Regulatory Cells is Not Essential for Their Suppressive Function in CNS Autoimmune Disease or Colitis
por: McPherson, Rhoanne C., et al.
Publicado: (2015)

IL-38: A New Player in Inflammatory Autoimmune Disorders
por: Xie, Lihui, et al.
Publicado: (2019)

Gender May Influence the Immunosuppressive Actions of Prednisone in Young Patients With Inflammatory Bowel Disease
por: Lucafò, Marianna, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hmd1jo113hiu79aglto544qonl