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Genome-Wide DNA Methylation Pattern in Whole Blood Associated With Primary Intracerebral Hemorrhage

Primary intracerebral hemorrhage (ICH) is a significant cause of morbidity and mortality throughout the world. ICH is a multifactorial disease that emerges from interactions among multiple genetic and environmental factors. DNA methylation plays an important role in the etiology of complex traits an...

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Autores principales: Zhang, Yupeng, Long, Hongyu, Wang, Sai, Xiao, Wenbiao, Xiong, Meishan, Liu, Jianyi, Chen, Lei, Chen, Ruijuan, Wei, Xueli, Shu, Yi, Zeng, Yi, Zhang, Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414634/
https://www.ncbi.nlm.nih.gov/pubmed/34484198
http://dx.doi.org/10.3389/fimmu.2021.702244
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author Zhang, Yupeng
Long, Hongyu
Wang, Sai
Xiao, Wenbiao
Xiong, Meishan
Liu, Jianyi
Chen, Lei
Chen, Ruijuan
Wei, Xueli
Shu, Yi
Zeng, Yi
Zhang, Le
author_facet Zhang, Yupeng
Long, Hongyu
Wang, Sai
Xiao, Wenbiao
Xiong, Meishan
Liu, Jianyi
Chen, Lei
Chen, Ruijuan
Wei, Xueli
Shu, Yi
Zeng, Yi
Zhang, Le
author_sort Zhang, Yupeng
collection PubMed
description Primary intracerebral hemorrhage (ICH) is a significant cause of morbidity and mortality throughout the world. ICH is a multifactorial disease that emerges from interactions among multiple genetic and environmental factors. DNA methylation plays an important role in the etiology of complex traits and diseases. We used the Illumina Infinium Human Methylation 850k BeadChip to detect changes in DNA methylation in peripheral blood samples from patients with ICH and healthy controls to explore DNA methylation patterns in ICH. Here, we compared genomic DNA methylation patterns in whole blood from ICH patients (n = 30) and controls (n = 34). The ICH and control groups showed significantly different DNA methylation patterns at 1530 sites (p-value < 5.92E-08), with 1377 hypermethylated sites and 153 hypomethylated sites in ICH patients compared to the methylation status in healthy controls. A total of 371 hypermethylated sites and 35 hypomethylated sites were in promoters, while 738 hypermethylated sites and 67 hypomethylated sites were in coding regions. Furthermore, the differentially methylated genes between ICH patients and controls were largely related to inflammatory pathways. Abnormalities in the DNA methylation pattern identified in the peripheral blood of ICH patients may play an important role in the development of ICH and warranted further investigation.
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spelling pubmed-84146342021-09-04 Genome-Wide DNA Methylation Pattern in Whole Blood Associated With Primary Intracerebral Hemorrhage Zhang, Yupeng Long, Hongyu Wang, Sai Xiao, Wenbiao Xiong, Meishan Liu, Jianyi Chen, Lei Chen, Ruijuan Wei, Xueli Shu, Yi Zeng, Yi Zhang, Le Front Immunol Immunology Primary intracerebral hemorrhage (ICH) is a significant cause of morbidity and mortality throughout the world. ICH is a multifactorial disease that emerges from interactions among multiple genetic and environmental factors. DNA methylation plays an important role in the etiology of complex traits and diseases. We used the Illumina Infinium Human Methylation 850k BeadChip to detect changes in DNA methylation in peripheral blood samples from patients with ICH and healthy controls to explore DNA methylation patterns in ICH. Here, we compared genomic DNA methylation patterns in whole blood from ICH patients (n = 30) and controls (n = 34). The ICH and control groups showed significantly different DNA methylation patterns at 1530 sites (p-value < 5.92E-08), with 1377 hypermethylated sites and 153 hypomethylated sites in ICH patients compared to the methylation status in healthy controls. A total of 371 hypermethylated sites and 35 hypomethylated sites were in promoters, while 738 hypermethylated sites and 67 hypomethylated sites were in coding regions. Furthermore, the differentially methylated genes between ICH patients and controls were largely related to inflammatory pathways. Abnormalities in the DNA methylation pattern identified in the peripheral blood of ICH patients may play an important role in the development of ICH and warranted further investigation. Frontiers Media S.A. 2021-08-13 /pmc/articles/PMC8414634/ /pubmed/34484198 http://dx.doi.org/10.3389/fimmu.2021.702244 Text en Copyright © 2021 Zhang, Long, Wang, Xiao, Xiong, Liu, Chen, Chen, Wei, Shu, Zeng and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Yupeng
Long, Hongyu
Wang, Sai
Xiao, Wenbiao
Xiong, Meishan
Liu, Jianyi
Chen, Lei
Chen, Ruijuan
Wei, Xueli
Shu, Yi
Zeng, Yi
Zhang, Le
Genome-Wide DNA Methylation Pattern in Whole Blood Associated With Primary Intracerebral Hemorrhage
title Genome-Wide DNA Methylation Pattern in Whole Blood Associated With Primary Intracerebral Hemorrhage
title_full Genome-Wide DNA Methylation Pattern in Whole Blood Associated With Primary Intracerebral Hemorrhage
title_fullStr Genome-Wide DNA Methylation Pattern in Whole Blood Associated With Primary Intracerebral Hemorrhage
title_full_unstemmed Genome-Wide DNA Methylation Pattern in Whole Blood Associated With Primary Intracerebral Hemorrhage
title_short Genome-Wide DNA Methylation Pattern in Whole Blood Associated With Primary Intracerebral Hemorrhage
title_sort genome-wide dna methylation pattern in whole blood associated with primary intracerebral hemorrhage
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414634/
https://www.ncbi.nlm.nih.gov/pubmed/34484198
http://dx.doi.org/10.3389/fimmu.2021.702244
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