RNA m(6)A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis

N(6)-methyladenosine (m(6)A) is a commonly modification of mammalian mRNAs and plays key roles in various cellular processes. Emerging evidence reveals the importance of RNA m(6)A modification in maintaining stem cell function in normal hematopoiesis and leukemogenesis. In this review, we first brie...

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Autores principales: Wang, Peipei, Feng, Mengdie, Han, Guoqiang, Yin, Rong, Li, Yashu, Yao, Shuxin, Lu, Pengbo, Wang, Yuhua, Zhang, Haojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414639/
https://www.ncbi.nlm.nih.gov/pubmed/34485297
http://dx.doi.org/10.3389/fcell.2021.710964
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author Wang, Peipei
Feng, Mengdie
Han, Guoqiang
Yin, Rong
Li, Yashu
Yao, Shuxin
Lu, Pengbo
Wang, Yuhua
Zhang, Haojian
author_facet Wang, Peipei
Feng, Mengdie
Han, Guoqiang
Yin, Rong
Li, Yashu
Yao, Shuxin
Lu, Pengbo
Wang, Yuhua
Zhang, Haojian
author_sort Wang, Peipei
collection PubMed
description N(6)-methyladenosine (m(6)A) is a commonly modification of mammalian mRNAs and plays key roles in various cellular processes. Emerging evidence reveals the importance of RNA m(6)A modification in maintaining stem cell function in normal hematopoiesis and leukemogenesis. In this review, we first briefly summarize the latest advances in RNA m(6)A biology, and further highlight the roles of m(6)A writers, readers and erasers in normal hematopoiesis and acute myeloid leukemia. Moreover, we also discuss the mechanisms of these m(6)A modifiers in preserving the function of hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs), as well as potential strategies for targeting m(6)A modification related pathways. Overall, we provide a comprehensive summary and our insights into the field of RNA m(6)A in normal hematopoiesis and leukemia pathogenesis.
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spelling pubmed-84146392021-09-04 RNA m(6)A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis Wang, Peipei Feng, Mengdie Han, Guoqiang Yin, Rong Li, Yashu Yao, Shuxin Lu, Pengbo Wang, Yuhua Zhang, Haojian Front Cell Dev Biol Cell and Developmental Biology N(6)-methyladenosine (m(6)A) is a commonly modification of mammalian mRNAs and plays key roles in various cellular processes. Emerging evidence reveals the importance of RNA m(6)A modification in maintaining stem cell function in normal hematopoiesis and leukemogenesis. In this review, we first briefly summarize the latest advances in RNA m(6)A biology, and further highlight the roles of m(6)A writers, readers and erasers in normal hematopoiesis and acute myeloid leukemia. Moreover, we also discuss the mechanisms of these m(6)A modifiers in preserving the function of hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs), as well as potential strategies for targeting m(6)A modification related pathways. Overall, we provide a comprehensive summary and our insights into the field of RNA m(6)A in normal hematopoiesis and leukemia pathogenesis. Frontiers Media S.A. 2021-08-13 /pmc/articles/PMC8414639/ /pubmed/34485297 http://dx.doi.org/10.3389/fcell.2021.710964 Text en Copyright © 2021 Wang, Feng, Han, Yin, Li, Yao, Lu, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wang, Peipei
Feng, Mengdie
Han, Guoqiang
Yin, Rong
Li, Yashu
Yao, Shuxin
Lu, Pengbo
Wang, Yuhua
Zhang, Haojian
RNA m(6)A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis
title RNA m(6)A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis
title_full RNA m(6)A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis
title_fullStr RNA m(6)A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis
title_full_unstemmed RNA m(6)A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis
title_short RNA m(6)A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis
title_sort rna m(6)a modification plays a key role in maintaining stem cell function in normal and malignant hematopoiesis
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414639/
https://www.ncbi.nlm.nih.gov/pubmed/34485297
http://dx.doi.org/10.3389/fcell.2021.710964
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