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A Topographic Atlas of the Human Brainstem in the Ponto-Mesencephalic Junction Plane

The human brainstem harbors neuronal aggregates that ensure the maintenance of several vital functions. It also acts as a major relay structure for the neuronal information that travels between the cerebral cortex, the cerebellum and the spinal cord. As such, this relatively small portion of the hum...

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Autores principales: Coulombe, Vincent, Saikali, Stephan, Goetz, Laurent, Takech, Mohamad A., Philippe, Éric, Parent, André, Parent, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414831/
https://www.ncbi.nlm.nih.gov/pubmed/34483849
http://dx.doi.org/10.3389/fnana.2021.627656
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author Coulombe, Vincent
Saikali, Stephan
Goetz, Laurent
Takech, Mohamad A.
Philippe, Éric
Parent, André
Parent, Martin
author_facet Coulombe, Vincent
Saikali, Stephan
Goetz, Laurent
Takech, Mohamad A.
Philippe, Éric
Parent, André
Parent, Martin
author_sort Coulombe, Vincent
collection PubMed
description The human brainstem harbors neuronal aggregates that ensure the maintenance of several vital functions. It also acts as a major relay structure for the neuronal information that travels between the cerebral cortex, the cerebellum and the spinal cord. As such, this relatively small portion of the human brain houses a multitude of ascending and descending fibers that course among numerous nuclei whose exact boundaries are still uncertain. Such a large number of nuclei and fiber tracts confined to a relatively small and compact brain region imposes upon the brainstem a highly complex cytoarchitectonic organization that still needs to be deciphered. The present work provides a topographic atlas of the human brainstem composed of 45 anatomical plates, each containing a pair of adjacent sections stained with Cresyl Violet and Luxol Fast Blue to help delineating brainstem nuclei and fiber tracts, respectively. The plates, which cover the entire midbrain, pons and medulla oblongata, are composed of equally-spaced sections referenced and aligned parallel to the ponto-mesencephalic junction rather than the fastigium or the obex. This topographic landmark is particularly suitable for neurosurgical interventions aiming at specific nuclei of the mesencephalic tegmentum. In complement, we provide 8 anatomical plates containing adjacent sections stained for choline acetyltransferase and Luxol Fast Blue, taken through the midbrain and the pons. This open access atlas of the human brainstem is intended to assist neuroanatomists, neurosurgeons and neuropathologists in their work.
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spelling pubmed-84148312021-09-04 A Topographic Atlas of the Human Brainstem in the Ponto-Mesencephalic Junction Plane Coulombe, Vincent Saikali, Stephan Goetz, Laurent Takech, Mohamad A. Philippe, Éric Parent, André Parent, Martin Front Neuroanat Neuroscience The human brainstem harbors neuronal aggregates that ensure the maintenance of several vital functions. It also acts as a major relay structure for the neuronal information that travels between the cerebral cortex, the cerebellum and the spinal cord. As such, this relatively small portion of the human brain houses a multitude of ascending and descending fibers that course among numerous nuclei whose exact boundaries are still uncertain. Such a large number of nuclei and fiber tracts confined to a relatively small and compact brain region imposes upon the brainstem a highly complex cytoarchitectonic organization that still needs to be deciphered. The present work provides a topographic atlas of the human brainstem composed of 45 anatomical plates, each containing a pair of adjacent sections stained with Cresyl Violet and Luxol Fast Blue to help delineating brainstem nuclei and fiber tracts, respectively. The plates, which cover the entire midbrain, pons and medulla oblongata, are composed of equally-spaced sections referenced and aligned parallel to the ponto-mesencephalic junction rather than the fastigium or the obex. This topographic landmark is particularly suitable for neurosurgical interventions aiming at specific nuclei of the mesencephalic tegmentum. In complement, we provide 8 anatomical plates containing adjacent sections stained for choline acetyltransferase and Luxol Fast Blue, taken through the midbrain and the pons. This open access atlas of the human brainstem is intended to assist neuroanatomists, neurosurgeons and neuropathologists in their work. Frontiers Media S.A. 2021-08-13 /pmc/articles/PMC8414831/ /pubmed/34483849 http://dx.doi.org/10.3389/fnana.2021.627656 Text en Copyright © 2021 Coulombe, Saikali, Goetz, Takech, Philippe, Parent and Parent. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Coulombe, Vincent
Saikali, Stephan
Goetz, Laurent
Takech, Mohamad A.
Philippe, Éric
Parent, André
Parent, Martin
A Topographic Atlas of the Human Brainstem in the Ponto-Mesencephalic Junction Plane
title A Topographic Atlas of the Human Brainstem in the Ponto-Mesencephalic Junction Plane
title_full A Topographic Atlas of the Human Brainstem in the Ponto-Mesencephalic Junction Plane
title_fullStr A Topographic Atlas of the Human Brainstem in the Ponto-Mesencephalic Junction Plane
title_full_unstemmed A Topographic Atlas of the Human Brainstem in the Ponto-Mesencephalic Junction Plane
title_short A Topographic Atlas of the Human Brainstem in the Ponto-Mesencephalic Junction Plane
title_sort topographic atlas of the human brainstem in the ponto-mesencephalic junction plane
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414831/
https://www.ncbi.nlm.nih.gov/pubmed/34483849
http://dx.doi.org/10.3389/fnana.2021.627656
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