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Significance of High-Containment Biological Laboratories Performing Work During the COVID-19 Pandemic: Biosafety Level-3 and -4 Labs
High containment biological laboratories (HCBL) are required for work on Risk Group 3 and 4 agents across the spectrum of basic, applied, and translational research. These laboratories include biosafety level (BSL)-3, BSL-4, animal BSL (ABSL)-3, BSL-3-Ag (agriculture livestock), and ABSL-4 laborator...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414973/ https://www.ncbi.nlm.nih.gov/pubmed/34485259 http://dx.doi.org/10.3389/fbioe.2021.720315 |
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author | Yeh, Kenneth B. Tabynov, Kairat Parekh, Falgunee K. Mombo, Illich Parker, Kyle Tabynov, Kaissar Bradrick, Shelton S. Tseng, Ashley S. Yang, Ji-Rong Gardiner, Lolly Olinger, Gene Setser, Bradly |
author_facet | Yeh, Kenneth B. Tabynov, Kairat Parekh, Falgunee K. Mombo, Illich Parker, Kyle Tabynov, Kaissar Bradrick, Shelton S. Tseng, Ashley S. Yang, Ji-Rong Gardiner, Lolly Olinger, Gene Setser, Bradly |
author_sort | Yeh, Kenneth B. |
collection | PubMed |
description | High containment biological laboratories (HCBL) are required for work on Risk Group 3 and 4 agents across the spectrum of basic, applied, and translational research. These laboratories include biosafety level (BSL)-3, BSL-4, animal BSL (ABSL)-3, BSL-3-Ag (agriculture livestock), and ABSL-4 laboratories. While SARS-CoV-2 is classified as a Risk Group 3 biological agent, routine diagnostic can be handled at BSL-2. Scenarios involving virus culture, potential exposure to aerosols, divergent high transmissible variants, and zoonosis from laboratory animals require higher BSL-3 measures. Establishing HCBLs especially those at BSL-4 is costly and needs continual investments of resources and funding to sustain labor, equipment, infrastructure, certifications, and operational needs. There are now over 50 BSL-4 laboratories and numerous BSL-3 laboratories worldwide. Besides technical and funding challenges, there are biosecurity and dual-use risks, and local community issues to contend with in order to sustain operations. Here, we describe case histories for distinct HCBLs: representative national centers for diagnostic and reference, nonprofit organizations. Case histories describe capabilities and assess activities during COVID-19 and include capacities, gaps, successes, and summary of lessons learned for future practice. |
format | Online Article Text |
id | pubmed-8414973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84149732021-09-04 Significance of High-Containment Biological Laboratories Performing Work During the COVID-19 Pandemic: Biosafety Level-3 and -4 Labs Yeh, Kenneth B. Tabynov, Kairat Parekh, Falgunee K. Mombo, Illich Parker, Kyle Tabynov, Kaissar Bradrick, Shelton S. Tseng, Ashley S. Yang, Ji-Rong Gardiner, Lolly Olinger, Gene Setser, Bradly Front Bioeng Biotechnol Bioengineering and Biotechnology High containment biological laboratories (HCBL) are required for work on Risk Group 3 and 4 agents across the spectrum of basic, applied, and translational research. These laboratories include biosafety level (BSL)-3, BSL-4, animal BSL (ABSL)-3, BSL-3-Ag (agriculture livestock), and ABSL-4 laboratories. While SARS-CoV-2 is classified as a Risk Group 3 biological agent, routine diagnostic can be handled at BSL-2. Scenarios involving virus culture, potential exposure to aerosols, divergent high transmissible variants, and zoonosis from laboratory animals require higher BSL-3 measures. Establishing HCBLs especially those at BSL-4 is costly and needs continual investments of resources and funding to sustain labor, equipment, infrastructure, certifications, and operational needs. There are now over 50 BSL-4 laboratories and numerous BSL-3 laboratories worldwide. Besides technical and funding challenges, there are biosecurity and dual-use risks, and local community issues to contend with in order to sustain operations. Here, we describe case histories for distinct HCBLs: representative national centers for diagnostic and reference, nonprofit organizations. Case histories describe capabilities and assess activities during COVID-19 and include capacities, gaps, successes, and summary of lessons learned for future practice. Frontiers Media S.A. 2021-08-13 /pmc/articles/PMC8414973/ /pubmed/34485259 http://dx.doi.org/10.3389/fbioe.2021.720315 Text en Copyright © 2021 Yeh, Tabynov, Parekh, Mombo, Parker, Tabynov, Bradrick, Tseng, Yang, Gardiner, Olinger and Setser. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Yeh, Kenneth B. Tabynov, Kairat Parekh, Falgunee K. Mombo, Illich Parker, Kyle Tabynov, Kaissar Bradrick, Shelton S. Tseng, Ashley S. Yang, Ji-Rong Gardiner, Lolly Olinger, Gene Setser, Bradly Significance of High-Containment Biological Laboratories Performing Work During the COVID-19 Pandemic: Biosafety Level-3 and -4 Labs |
title | Significance of High-Containment Biological Laboratories Performing Work During the COVID-19 Pandemic: Biosafety Level-3 and -4 Labs |
title_full | Significance of High-Containment Biological Laboratories Performing Work During the COVID-19 Pandemic: Biosafety Level-3 and -4 Labs |
title_fullStr | Significance of High-Containment Biological Laboratories Performing Work During the COVID-19 Pandemic: Biosafety Level-3 and -4 Labs |
title_full_unstemmed | Significance of High-Containment Biological Laboratories Performing Work During the COVID-19 Pandemic: Biosafety Level-3 and -4 Labs |
title_short | Significance of High-Containment Biological Laboratories Performing Work During the COVID-19 Pandemic: Biosafety Level-3 and -4 Labs |
title_sort | significance of high-containment biological laboratories performing work during the covid-19 pandemic: biosafety level-3 and -4 labs |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8414973/ https://www.ncbi.nlm.nih.gov/pubmed/34485259 http://dx.doi.org/10.3389/fbioe.2021.720315 |
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