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Computer-Aided Rational Engineering of Signal Sensitivity of Quorum Sensing Protein LuxR in a Whole-Cell Biosensor

LuxR, a bacterial quorum sensing-related transcription factor that responds to the signaling molecule 3-oxo-hexanoyl-homoserine lactone (3OC6-HSL). In this study, we employed molecular dynamics simulation and the Molecular Mechanics Generalized Born Surface Area (MM-GB/SA) method to rationally ident...

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Detalles Bibliográficos
Autores principales:	Li, Jinyu, Liu, Ruicun, Chen, Yulu, Liu, Shuxia, Chen, Cheng, Liu, Tuoyu, Yang, Shan, Zhuang, Yingtan, Yang, Ruifu, Cui, Yujun, Song, Yajun, Wang, Tao, Teng, Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415086/ https://www.ncbi.nlm.nih.gov/pubmed/34485387 http://dx.doi.org/10.3389/fmolb.2021.729350

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