Liraglutide via Activation of AMP-Activated Protein Kinase-Hypoxia Inducible Factor-1α-Heme Oxygenase-1 Signaling Promotes Wound Healing by Preventing Endothelial Dysfunction in Diabetic Mice

Background/Aims: Diabetic foot ulcers (DFUs) present a major challenge in clinical practice, and hyperglycemia-induced angiogenesis disturbance and endothelial dysfunction likely exacerbate DFUs. The long-acting glucagon-like peptide-1 (GLP-1) analog liraglutide (Lira) is a potential activator of AM...

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Detalles Bibliográficos
Autores principales: Huang, Huiya, Wang, Linlin, Qian, Fanyu, Chen, Xiong, Zhu, Haiping, Yang, Mei, Zhang, Chunxiang, Chu, Maoping, Wang, Xiaorong, Huang, Xiaozhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415222/
https://www.ncbi.nlm.nih.gov/pubmed/34483951
http://dx.doi.org/10.3389/fphys.2021.660263

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