Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism

SARS-CoV-2 infection during pregnancy is not usually associated with significant adverse effects. However, in this study, we report a fetal death associated with mild COVID-19 in a 34-week-pregnant woman. The virus was detected in the placenta and in an unprecedented way in several fetal tissues. Pl...

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Autores principales: Marinho, Penélope Saldanha, da Cunha, Antonio José Ledo Alves, Chimelli, Leila, Avvad-Portari, Elyzabeth, Andreiuolo, Felipe da Matta, de Oliveira-Szejnfeld, Patrícia Soares, Mendes, Mayara Abud, Gomes, Ismael Carlos, Souza, Letícia Rocha Q., Guimarães, Marilia Zaluar, Goldman, Suzan Menasce, de Oliveira, Mariana Barros Genuíno, Rehen, Stevens, Amim, Joffre, Tovar-Moll, Fernanda, Prata-Barbosa, Arnaldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415358/
https://www.ncbi.nlm.nih.gov/pubmed/34485327
http://dx.doi.org/10.3389/fmed.2021.677001
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author Marinho, Penélope Saldanha
da Cunha, Antonio José Ledo Alves
Chimelli, Leila
Avvad-Portari, Elyzabeth
Andreiuolo, Felipe da Matta
de Oliveira-Szejnfeld, Patrícia Soares
Mendes, Mayara Abud
Gomes, Ismael Carlos
Souza, Letícia Rocha Q.
Guimarães, Marilia Zaluar
Goldman, Suzan Menasce
de Oliveira, Mariana Barros Genuíno
Rehen, Stevens
Amim, Joffre
Tovar-Moll, Fernanda
Prata-Barbosa, Arnaldo
author_facet Marinho, Penélope Saldanha
da Cunha, Antonio José Ledo Alves
Chimelli, Leila
Avvad-Portari, Elyzabeth
Andreiuolo, Felipe da Matta
de Oliveira-Szejnfeld, Patrícia Soares
Mendes, Mayara Abud
Gomes, Ismael Carlos
Souza, Letícia Rocha Q.
Guimarães, Marilia Zaluar
Goldman, Suzan Menasce
de Oliveira, Mariana Barros Genuíno
Rehen, Stevens
Amim, Joffre
Tovar-Moll, Fernanda
Prata-Barbosa, Arnaldo
author_sort Marinho, Penélope Saldanha
collection PubMed
description SARS-CoV-2 infection during pregnancy is not usually associated with significant adverse effects. However, in this study, we report a fetal death associated with mild COVID-19 in a 34-week-pregnant woman. The virus was detected in the placenta and in an unprecedented way in several fetal tissues. Placental abnormalities (MRI and anatomopathological study) were consistent with intense vascular malperfusion, probably the cause of fetal death. Lung histopathology also showed signs of inflammation, which could have been a contributory factor. Monitoring inflammatory response and coagulation in high-risk pregnant women with COVID-19 may prevent unfavorable outcomes, as shown in this case.
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spelling pubmed-84153582021-09-04 Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism Marinho, Penélope Saldanha da Cunha, Antonio José Ledo Alves Chimelli, Leila Avvad-Portari, Elyzabeth Andreiuolo, Felipe da Matta de Oliveira-Szejnfeld, Patrícia Soares Mendes, Mayara Abud Gomes, Ismael Carlos Souza, Letícia Rocha Q. Guimarães, Marilia Zaluar Goldman, Suzan Menasce de Oliveira, Mariana Barros Genuíno Rehen, Stevens Amim, Joffre Tovar-Moll, Fernanda Prata-Barbosa, Arnaldo Front Med (Lausanne) Medicine SARS-CoV-2 infection during pregnancy is not usually associated with significant adverse effects. However, in this study, we report a fetal death associated with mild COVID-19 in a 34-week-pregnant woman. The virus was detected in the placenta and in an unprecedented way in several fetal tissues. Placental abnormalities (MRI and anatomopathological study) were consistent with intense vascular malperfusion, probably the cause of fetal death. Lung histopathology also showed signs of inflammation, which could have been a contributory factor. Monitoring inflammatory response and coagulation in high-risk pregnant women with COVID-19 may prevent unfavorable outcomes, as shown in this case. Frontiers Media S.A. 2021-08-16 /pmc/articles/PMC8415358/ /pubmed/34485327 http://dx.doi.org/10.3389/fmed.2021.677001 Text en Copyright © 2021 Marinho, da Cunha, Chimelli, Avvad-Portari, Andreiuolo, de Oliveira-Szejnfeld, Mendes, Gomes, Souza, Guimarães, Goldman, de Oliveira, Rehen, Amim, Tovar-Moll and Prata-Barbosa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Marinho, Penélope Saldanha
da Cunha, Antonio José Ledo Alves
Chimelli, Leila
Avvad-Portari, Elyzabeth
Andreiuolo, Felipe da Matta
de Oliveira-Szejnfeld, Patrícia Soares
Mendes, Mayara Abud
Gomes, Ismael Carlos
Souza, Letícia Rocha Q.
Guimarães, Marilia Zaluar
Goldman, Suzan Menasce
de Oliveira, Mariana Barros Genuíno
Rehen, Stevens
Amim, Joffre
Tovar-Moll, Fernanda
Prata-Barbosa, Arnaldo
Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism
title Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism
title_full Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism
title_fullStr Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism
title_full_unstemmed Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism
title_short Case Report: SARS-CoV-2 Mother-to-Child Transmission and Fetal Death Associated With Severe Placental Thromboembolism
title_sort case report: sars-cov-2 mother-to-child transmission and fetal death associated with severe placental thromboembolism
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415358/
https://www.ncbi.nlm.nih.gov/pubmed/34485327
http://dx.doi.org/10.3389/fmed.2021.677001
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