Ligand-induced native G-quadruplex stabilization impairs transcription initiation

G-quadruplexes (G4s) are noncanonical DNA secondary structures formed through the self-association of guanines, and G4s are distributed widely across the genome. G4 participates in multiple biological processes including gene transcription, and G4-targeted ligands serve as potential therapeutic agen...

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Detalles Bibliográficos
Autores principales: Li, Conghui, Wang, Honghong, Yin, Zhinang, Fang, Pingping, Xiao, Ruijing, Xiang, Ying, Wang, Wen, Li, Qiuzi, Huang, Beili, Huang, Jian, Liang, Kaiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415369/
https://www.ncbi.nlm.nih.gov/pubmed/34400476
http://dx.doi.org/10.1101/gr.275431.121

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