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Sequence-based correction of barcode bias in massively parallel reporter assays

Massively parallel reporter assays (MPRAs) are a high-throughput method for evaluating in vitro activities of thousands of candidate cis-regulatory elements (CREs). In these assays, candidate sequences are cloned upstream or downstream from a reporter gene tagged by unique DNA sequences. However, ta...

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Detalles Bibliográficos
Autores principales:	Lee, Dongwon, Kapoor, Ashish, Lee, Changhee, Mudgett, Michael, Beer, Michael A., Chakravarti, Aravinda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2021
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415370/ https://www.ncbi.nlm.nih.gov/pubmed/34285053 http://dx.doi.org/10.1101/gr.268599.120

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