Type 2 Diabetes Mellitus Intersects With Pancreatic Cancer Diagnosis and Development

The relationship between type 2 diabetes mellitus (T2DM) and pancreatic cancer (PC) is complex. Diabetes is a known risk factor for PC, and new-onset diabetes (NOD) could be an early manifestation of PC that may be facilitate the early diagnosis of PC. Metformin offers a clear benefit of inhibiting...

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Detalles Bibliográficos
Autores principales: Duan, Xiaoye, Wang, Weihao, Pan, Qi, Guo, Lixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415500/
https://www.ncbi.nlm.nih.gov/pubmed/34485159
http://dx.doi.org/10.3389/fonc.2021.730038
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author Duan, Xiaoye
Wang, Weihao
Pan, Qi
Guo, Lixin
author_facet Duan, Xiaoye
Wang, Weihao
Pan, Qi
Guo, Lixin
author_sort Duan, Xiaoye
collection PubMed
description The relationship between type 2 diabetes mellitus (T2DM) and pancreatic cancer (PC) is complex. Diabetes is a known risk factor for PC, and new-onset diabetes (NOD) could be an early manifestation of PC that may be facilitate the early diagnosis of PC. Metformin offers a clear benefit of inhibiting PC, whereas insulin therapy may increase the risk of PC development. No evidence has shown that novel hypoglycemic drugs help or prevent PC. In this review, the effects of T2DM on PC development are summarized, and novel strategies for the prevention and treatment of T2DM and PC are discussed.
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spelling pubmed-84155002021-09-04 Type 2 Diabetes Mellitus Intersects With Pancreatic Cancer Diagnosis and Development Duan, Xiaoye Wang, Weihao Pan, Qi Guo, Lixin Front Oncol Oncology The relationship between type 2 diabetes mellitus (T2DM) and pancreatic cancer (PC) is complex. Diabetes is a known risk factor for PC, and new-onset diabetes (NOD) could be an early manifestation of PC that may be facilitate the early diagnosis of PC. Metformin offers a clear benefit of inhibiting PC, whereas insulin therapy may increase the risk of PC development. No evidence has shown that novel hypoglycemic drugs help or prevent PC. In this review, the effects of T2DM on PC development are summarized, and novel strategies for the prevention and treatment of T2DM and PC are discussed. Frontiers Media S.A. 2021-08-16 /pmc/articles/PMC8415500/ /pubmed/34485159 http://dx.doi.org/10.3389/fonc.2021.730038 Text en Copyright © 2021 Duan, Wang, Pan and Guo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Duan, Xiaoye
Wang, Weihao
Pan, Qi
Guo, Lixin
Type 2 Diabetes Mellitus Intersects With Pancreatic Cancer Diagnosis and Development
title Type 2 Diabetes Mellitus Intersects With Pancreatic Cancer Diagnosis and Development
title_full Type 2 Diabetes Mellitus Intersects With Pancreatic Cancer Diagnosis and Development
title_fullStr Type 2 Diabetes Mellitus Intersects With Pancreatic Cancer Diagnosis and Development
title_full_unstemmed Type 2 Diabetes Mellitus Intersects With Pancreatic Cancer Diagnosis and Development
title_short Type 2 Diabetes Mellitus Intersects With Pancreatic Cancer Diagnosis and Development
title_sort type 2 diabetes mellitus intersects with pancreatic cancer diagnosis and development
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415500/
https://www.ncbi.nlm.nih.gov/pubmed/34485159
http://dx.doi.org/10.3389/fonc.2021.730038
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AT panqi type2diabetesmellitusintersectswithpancreaticcancerdiagnosisanddevelopment
AT guolixin type2diabetesmellitusintersectswithpancreaticcancerdiagnosisanddevelopment

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