Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation

Background and Purpose: Doxorubicin (DOX) is a risk factor for arm lymphedema in breast cancer patients. We reported that DOX opens ryanodine receptors (RYRs) to enact “calcium leak,” which disrupts the rhythmic contractions of lymph vessels (LVs) to attenuate lymph flow. Here, we evaluated whether...

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Detalles Bibliográficos
Autores principales: Van, Serena, Pal, Soumiya, Garner, Brittney R., Steed, Kate, Sridharan, Vijayalakshmi, Mu, Shengyu, Rusch, Nancy J., Stolarz, Amanda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415554/
https://www.ncbi.nlm.nih.gov/pubmed/34483938
http://dx.doi.org/10.3389/fphar.2021.727526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415554/
https://www.ncbi.nlm.nih.gov/pubmed/34483938
http://dx.doi.org/10.3389/fphar.2021.727526

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