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Widespread Disruptions of White Matter in Familial Multiple Sclerosis: DTI and NODDI Study

Diffusion tensor imaging (DTI) is a noninvasive, quantitative MRI technique that measures white matter (WM) integrity. Many brain dimensions are heritable, including white matter integrity measured with DTI. Family studies are valuable to provide insights into the interactive effects of non-environm...

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Autores principales: Gharaylou, Zeinab, Sahraian, Mohammad Ali, Hadjighassem, Mahmoudreza, Kohanpour, Mohsen, Doosti, Rozita, Nahardani, Shima, Moghadasi, Abdorreza Naser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415561/
https://www.ncbi.nlm.nih.gov/pubmed/34484098
http://dx.doi.org/10.3389/fneur.2021.678245
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author Gharaylou, Zeinab
Sahraian, Mohammad Ali
Hadjighassem, Mahmoudreza
Kohanpour, Mohsen
Doosti, Rozita
Nahardani, Shima
Moghadasi, Abdorreza Naser
author_facet Gharaylou, Zeinab
Sahraian, Mohammad Ali
Hadjighassem, Mahmoudreza
Kohanpour, Mohsen
Doosti, Rozita
Nahardani, Shima
Moghadasi, Abdorreza Naser
author_sort Gharaylou, Zeinab
collection PubMed
description Diffusion tensor imaging (DTI) is a noninvasive, quantitative MRI technique that measures white matter (WM) integrity. Many brain dimensions are heritable, including white matter integrity measured with DTI. Family studies are valuable to provide insights into the interactive effects of non-environmental factors on multiple sclerosis (MS). To examine the contribution of familial factors to the diffusion signals across WM microstructure, we performed DTI and calculated neurite orientation dispersion plus density imaging (NODDI) diffusion parameters in two patient groups comprising familial and sporadic forms of multiple sclerosis and their unaffected relatives. We divided 111 subjects (49 men and 62 women: age range 19–60) into three groups conforming to their MS history. The familial MS group included 30 participants (patients; n = 16, healthy relatives; n = 14). The sporadic group included 41 participants (patients; n = 10, healthy relatives; n = 31). Forty age-matched subjects with no history of MS in their families were defined as the control group. To study white matter integrity, two methods were employed: one for calculating the mean of DTI, FA, and MD parameters on 18 tracts using Tracts Constrained by Underlying Anatomy (TRACULA) and the other for whole brain voxel-based analysis using tract-based spatial statistics (TBSS) on NDI and ODI parameters derived from NODDI and DTI parameters. Voxel-based analysis showed considerable changes in FA, MD, NDI, and ODI in the familial group when compared with the control group, reflecting widespread impairment of white matter in this group. The analysis of 18 tracts with TRACULA revealed increased MD and FA reduction in more tracts (left and right ILF, UNC, and SLFT, forceps major and minor) in familial MS patients vs. the control group. There were no significant differences between the patient groups. We found no consequential changes in healthy relatives of both patient groups in voxel-based and tract analyses. Considering the multifactorial etiology of MS, familial studies are of great importance to clarify the effects of certain predisposing factors on demyelinating brain pathology.
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spelling pubmed-84155612021-09-04 Widespread Disruptions of White Matter in Familial Multiple Sclerosis: DTI and NODDI Study Gharaylou, Zeinab Sahraian, Mohammad Ali Hadjighassem, Mahmoudreza Kohanpour, Mohsen Doosti, Rozita Nahardani, Shima Moghadasi, Abdorreza Naser Front Neurol Neurology Diffusion tensor imaging (DTI) is a noninvasive, quantitative MRI technique that measures white matter (WM) integrity. Many brain dimensions are heritable, including white matter integrity measured with DTI. Family studies are valuable to provide insights into the interactive effects of non-environmental factors on multiple sclerosis (MS). To examine the contribution of familial factors to the diffusion signals across WM microstructure, we performed DTI and calculated neurite orientation dispersion plus density imaging (NODDI) diffusion parameters in two patient groups comprising familial and sporadic forms of multiple sclerosis and their unaffected relatives. We divided 111 subjects (49 men and 62 women: age range 19–60) into three groups conforming to their MS history. The familial MS group included 30 participants (patients; n = 16, healthy relatives; n = 14). The sporadic group included 41 participants (patients; n = 10, healthy relatives; n = 31). Forty age-matched subjects with no history of MS in their families were defined as the control group. To study white matter integrity, two methods were employed: one for calculating the mean of DTI, FA, and MD parameters on 18 tracts using Tracts Constrained by Underlying Anatomy (TRACULA) and the other for whole brain voxel-based analysis using tract-based spatial statistics (TBSS) on NDI and ODI parameters derived from NODDI and DTI parameters. Voxel-based analysis showed considerable changes in FA, MD, NDI, and ODI in the familial group when compared with the control group, reflecting widespread impairment of white matter in this group. The analysis of 18 tracts with TRACULA revealed increased MD and FA reduction in more tracts (left and right ILF, UNC, and SLFT, forceps major and minor) in familial MS patients vs. the control group. There were no significant differences between the patient groups. We found no consequential changes in healthy relatives of both patient groups in voxel-based and tract analyses. Considering the multifactorial etiology of MS, familial studies are of great importance to clarify the effects of certain predisposing factors on demyelinating brain pathology. Frontiers Media S.A. 2021-08-16 /pmc/articles/PMC8415561/ /pubmed/34484098 http://dx.doi.org/10.3389/fneur.2021.678245 Text en Copyright © 2021 Gharaylou, Sahraian, Hadjighassem, Kohanpour, Doosti, Nahardani and Moghadasi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Gharaylou, Zeinab
Sahraian, Mohammad Ali
Hadjighassem, Mahmoudreza
Kohanpour, Mohsen
Doosti, Rozita
Nahardani, Shima
Moghadasi, Abdorreza Naser
Widespread Disruptions of White Matter in Familial Multiple Sclerosis: DTI and NODDI Study
title Widespread Disruptions of White Matter in Familial Multiple Sclerosis: DTI and NODDI Study
title_full Widespread Disruptions of White Matter in Familial Multiple Sclerosis: DTI and NODDI Study
title_fullStr Widespread Disruptions of White Matter in Familial Multiple Sclerosis: DTI and NODDI Study
title_full_unstemmed Widespread Disruptions of White Matter in Familial Multiple Sclerosis: DTI and NODDI Study
title_short Widespread Disruptions of White Matter in Familial Multiple Sclerosis: DTI and NODDI Study
title_sort widespread disruptions of white matter in familial multiple sclerosis: dti and noddi study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415561/
https://www.ncbi.nlm.nih.gov/pubmed/34484098
http://dx.doi.org/10.3389/fneur.2021.678245
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