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Longitudinal Changes in CT Body Composition in Patients Undergoing Surgery for Colorectal Cancer and Associations With Peri-Operative Clinicopathological Characteristics

There is evidence for the direct association between body composition, the magnitude of the systemic inflammatory response, and outcomes in patients with colorectal cancer. Patients with a primary operable disease with and without follow-up CT scans were examined in this study. CT scans were used to...

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Autores principales: Dolan, Ross D., Abbass, Tanvir, Sim, Wei M. J., Almasaudi, Arwa S., Dieu, Ly B., Horgan, Paul G., McSorley, Stephen T., McMillan, Donald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415565/
https://www.ncbi.nlm.nih.gov/pubmed/34485358
http://dx.doi.org/10.3389/fnut.2021.678410
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author Dolan, Ross D.
Abbass, Tanvir
Sim, Wei M. J.
Almasaudi, Arwa S.
Dieu, Ly B.
Horgan, Paul G.
McSorley, Stephen T.
McMillan, Donald C.
author_facet Dolan, Ross D.
Abbass, Tanvir
Sim, Wei M. J.
Almasaudi, Arwa S.
Dieu, Ly B.
Horgan, Paul G.
McSorley, Stephen T.
McMillan, Donald C.
author_sort Dolan, Ross D.
collection PubMed
description There is evidence for the direct association between body composition, the magnitude of the systemic inflammatory response, and outcomes in patients with colorectal cancer. Patients with a primary operable disease with and without follow-up CT scans were examined in this study. CT scans were used to define the presence and changes in subcutaneous fat, visceral fat, skeletal muscle mass, and skeletal muscle density (SMD). In total, 804 patients had follow-up scans and 83 patients did not. Furthermore, 783 (97%) patients with follow-up scans and 60 (72%) patients without follow-up scans were alive at 1 year. Patients with follow-up scans were younger (p < 0.001), had a lower American Society of Anaesthesiology Grade (p < 0.01), underwent a laparoscopic surgery (p < 0.05), had a higher BMI (p < 0.05), a higher skeletal muscle index (SMI) (p < 0.01), a higher SMD (p < 0.01), and a better 1-year survival (p < 0.001). Overall only 20% of the patients showed changes in their SMI (n = 161) and an even lower percentage of patients showed relative changes of 10% (n = 82) or more. In conclusion, over the period of ~12 months, a low–skeletal muscle mass was associated with a systemic inflammatory response and was largely maintained following surgical resection.
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spelling pubmed-84155652021-09-04 Longitudinal Changes in CT Body Composition in Patients Undergoing Surgery for Colorectal Cancer and Associations With Peri-Operative Clinicopathological Characteristics Dolan, Ross D. Abbass, Tanvir Sim, Wei M. J. Almasaudi, Arwa S. Dieu, Ly B. Horgan, Paul G. McSorley, Stephen T. McMillan, Donald C. Front Nutr Nutrition There is evidence for the direct association between body composition, the magnitude of the systemic inflammatory response, and outcomes in patients with colorectal cancer. Patients with a primary operable disease with and without follow-up CT scans were examined in this study. CT scans were used to define the presence and changes in subcutaneous fat, visceral fat, skeletal muscle mass, and skeletal muscle density (SMD). In total, 804 patients had follow-up scans and 83 patients did not. Furthermore, 783 (97%) patients with follow-up scans and 60 (72%) patients without follow-up scans were alive at 1 year. Patients with follow-up scans were younger (p < 0.001), had a lower American Society of Anaesthesiology Grade (p < 0.01), underwent a laparoscopic surgery (p < 0.05), had a higher BMI (p < 0.05), a higher skeletal muscle index (SMI) (p < 0.01), a higher SMD (p < 0.01), and a better 1-year survival (p < 0.001). Overall only 20% of the patients showed changes in their SMI (n = 161) and an even lower percentage of patients showed relative changes of 10% (n = 82) or more. In conclusion, over the period of ~12 months, a low–skeletal muscle mass was associated with a systemic inflammatory response and was largely maintained following surgical resection. Frontiers Media S.A. 2021-08-16 /pmc/articles/PMC8415565/ /pubmed/34485358 http://dx.doi.org/10.3389/fnut.2021.678410 Text en Copyright © 2021 Dolan, Abbass, Sim, Almasaudi, Dieu, Horgan, McSorley and McMillan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Dolan, Ross D.
Abbass, Tanvir
Sim, Wei M. J.
Almasaudi, Arwa S.
Dieu, Ly B.
Horgan, Paul G.
McSorley, Stephen T.
McMillan, Donald C.
Longitudinal Changes in CT Body Composition in Patients Undergoing Surgery for Colorectal Cancer and Associations With Peri-Operative Clinicopathological Characteristics
title Longitudinal Changes in CT Body Composition in Patients Undergoing Surgery for Colorectal Cancer and Associations With Peri-Operative Clinicopathological Characteristics
title_full Longitudinal Changes in CT Body Composition in Patients Undergoing Surgery for Colorectal Cancer and Associations With Peri-Operative Clinicopathological Characteristics
title_fullStr Longitudinal Changes in CT Body Composition in Patients Undergoing Surgery for Colorectal Cancer and Associations With Peri-Operative Clinicopathological Characteristics
title_full_unstemmed Longitudinal Changes in CT Body Composition in Patients Undergoing Surgery for Colorectal Cancer and Associations With Peri-Operative Clinicopathological Characteristics
title_short Longitudinal Changes in CT Body Composition in Patients Undergoing Surgery for Colorectal Cancer and Associations With Peri-Operative Clinicopathological Characteristics
title_sort longitudinal changes in ct body composition in patients undergoing surgery for colorectal cancer and associations with peri-operative clinicopathological characteristics
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415565/
https://www.ncbi.nlm.nih.gov/pubmed/34485358
http://dx.doi.org/10.3389/fnut.2021.678410
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